Vnitr Lek 2013, 59(5):402-406

Paraneoplastic hypoglyacemia

I. Ságová^*, A. Klimentová, D. Prídavková, D. Kantárová, J. Sadloňová, P. Galajda, M. Mokáň

I. interná klinika Jesseniovej lekárskej fakulty UK a UN Martin, Slovenská republika, prednosta prof. MUDr. Marián Mokáň, DrSc., FRCP Edin.

Paraneoplastic hypoglyacemia (PH) is a relatively rare phenomenon, which may be caused by insulinomas or non-islet cell tumours (NICT). Both types are among the major "fasting" hypoglyacemia as opposed to reactive postprandial hypoglyacemia. The most common group of non-islet cell tumours causing hypoaglycemia are large mesenchymal tumours, which account for over 50 % of all neoplasms associated with hypoglyacemia. Neuroglycopenic symptoms in patients with NICT may be present for months or years before the actual diagnosis of the underlying disease. Differentiation and correct diagnosis of this type of disease leads to significant improvement in the quality of life of these patients.

Keywords: paraneoplastic hypoaglycemia; non-islet cell tumors; diagnosis; therapy

Received: December 26, 2012; Accepted: February 28, 2013; Published: May 1, 2013  Show citation