Vnitr Lek 2012, 58(Suppl 2):20-26

Acute lymphoblastic leukemia: past and present

C. ©álek*, D. ©ponerová, J. Soukupová Maaloufová
Ústav hematologie a krevní transfuze Praha, ředitel prof. MUDr. Marek Trněný, CSc.

Acute lymphoblastic leukemia (ALL) is a rare neoplasm in adults. Its treatment has seen dynamic developments ranging from the discovery of first compounds with cytostatic effect through to the introduction of multicomponent chemotherapy, incorporation of hematopoietic stem cell transplantation into postconsolidation therapy as well as dose intensity adjustment according to defined risk groups. The basic therapeutical principle of present treatment strategies is an individualised approach. Modern protocols build on the prognostic significance of minimal residual disease and incorporate new drugs such as tyrosine kinase inhibitors, monoclonal antibodies or new forms of non-genotoxic drugs, for specific ALL subgroups. Long-term survival has significantly improved from < 1% 60 years ago to ~ 40% at present.

Keywords: acute lymphoblastic leukemia; risk factors; minimal residual disease; therapy; hematopoetic stem cell transplantation; history of UHKT

Received: May 17, 2012; Published: April 1, 2012  Show citation

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©álek C, ©ponerová D, Soukupová Maaloufová J. Acute lymphoblastic leukemia: past and present. Vnitr Lek. 2012;58(Supplementum 2):20-26.
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