Vnitr Lek 2012, 58(7-8):205-207

Chronic inflammation and the metabolic syndrome

Š. Svačina

III. interní klinika 1. lékařské fakulty UK a VFN Praha, přednosta prof. MUDr. Štěpán Svačina, DrSc., MBA

Metabolic syndrome is a disease associated with systemic inflammation. At present, metabolic syndrome is understood chiefly as an abdominal obesity with complications. Inflammatory signs then have the strongest association with the wasteline. Nevertheless, metabolic syndrome is most certainly also induced by an inflammation of a different origin. Metabolic syndrome is linked to typically inflammatory diseases such as paradontosis, rheumatoid diseases, chronic obstructive pulmonary disease and, to a large extent, psoriasis. The association is thus certainly reciprocal; metabolic syndrome causes inflammation and inflammatory diseases cause metabolic syndrome. Pathogenic relationships are unclear while it cannot be excluded that it is primarily an inflammation that causes metabolic syndrome and, in case of abdominal obesity without another inflammatory disease, this may be an inflammation in the abdominal fat.

Keywords: metabolic syndrome; type 2 diabetes mellitus; hypertension; paradontosis; C-reactive protein; chronic obstructive pulmonary disease; rheumatoid arthritis; psoriasis

Received: June 3, 2012; Published: July 1, 2012  Show citation