Vnitr Lek 2012, 58(7-8):175-180

High dose treatments and preparatory regimens prior to haematopoietic stem cell transplantation

M. Tomíška

Interní hematologická a onkologická klinika Lékařské fakulty MU a FN Brno, pracoviště Bohunice, přednosta prof. MUDr. Jiří Mayer, CSc.

High-dose chemotherapy can be defined as utilization of cytotoxic drug doses that produce bone marrow ablation. Transfusion of autologous graft serves as rescue from otherwise fatal myelotoxicity. Immune reaction of graft versus tumor that lowers relaps rates of malignant disease becomes an important contribution of allogeneic hematopoietic stem cell transplantation. New reduced intensity conditioning regimens with lower initial cytotoxicity rely on this immune effect with the potencial of additional elimination of remaining cancer cells. Decreased toxicity of these regimens enables treatment of patients with comorbidity and/or in higher age.

Keywords: high-dose chemotherapy; hematopoietic stem cell transplantation; conditioning regimen; nonmyeloablative conditioning

Received: March 28, 2012; Published: July 1, 2012  Show citation