Vnitr Lek 2012, 58(7-8):71-74

Oxidative stress and antioxidation systems in haemodialyzed patients

O. Rácz^1,2,*, M. Mydlík³, A. Chmelárová³, K. Derzsiová¹, D. Maceková¹, F. Ništiar¹, E. Lovásová¹, B. Fodor²

¹ Ústav patologickej fyziológie Lekárskej fakulty UPJŠ Košice, Slovenská republika, prednosta prof. MUDr. Oliver Rácz, CSc.

² Institute of Nanobiotechnology and Regenerative Medicine, Miskolc University, Hungary, head Fodor Bertalan, MSc, PhD, EurClinChem

³ Ústav experimentálnej medicíny Lekárskej fakulty UPJŠ, Košice, Slovenská republika, prednosta MVDr. Alojz Bomba, DrSc.

The authors present a critical analysis of current knowledge on oxidative stress and on the activity of antioxidative systems in patients with chronic kidney disease with a focus on haemodialysed patients. Even though oxidative stress in these patients is well documented, a number of questions remain unanswered. The overview describes pathobiochemistry of oxidative stress during haemodialysis, analysis of current knowledge on lipid peroxidation and antioxidant enzyme activity in the red blood cells in patients with this disease. Finally, the authors evaluate opinions on justifiability of exogenous supplementation of vitamins with antioxidant properties in patients on haemodialysis. They conclude that the use of vitamin E-containing membranes is the only evidenced option for reducing oxidative stress during haemodialysis.

Keywords: chronic kidney disease; haemodialysis; oxidative stress; antioxidative systems

Received: May 28, 2012; Published: July 1, 2012  Show citation