Vnitr Lek 2012, 58(4):305-308

Diabetes mellitus and dementia

I. Tůma
Psychiatrická klinika Lékařské fakulty UK a FN Hradec Králové, přednosta prof. MUDr. Jan Libiger, CSc.

Patients with diabetes are at increased risk of developing cognitive impairment in comparison with the general population. Diabetes mellitus increases the risk of dementia (vascular and/or neurodegenerative). Diabetes accelerates the progression from mild cognitive impairment to dementia. It has been estimated that type 2 diabetes or impairment of glucose metabolism might be present in up to 80% of patients with Alzheimer disease. The cognitive dysfunction is associated with poorer ability in diabetes self-care and decreased adherence to antidiabetic treatment.

Keywords: diabetes mellitus; cognition; dementia; Alzheimer disease

Received: November 7, 2011; Published: April 1, 2012  Show citation

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Tůma I. Diabetes mellitus and dementia. Vnitr Lek. 2012;58(4):305-308.
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    References

    1. Akisaki T, Sakurai T, Takata T et al. Cognitive dysfunction associates with white matter hyperintensities and subcortical atrophy on magnetic resonance imaging of the elderly diabetes mellitus Japanese elderly diabetes intervention trial (J-EDIT). Diabetes Metab Res Rev 2006; 22: 376-384. Go to original source... Go to PubMed...
    2. Akomolafe A, Beiser A, Meigs JB et al. Diabetes mellitus and risk of developing Alzheimer dinase: results from the Framingham Study. Arch Neurol 2006; 63: 1551-1555. Go to original source... Go to PubMed...
    3. Arvanitakis Z, Wilson RS, Bienias JL et al. Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function. Arch Neurol 2004; 61: 661-666. Go to original source... Go to PubMed...
    4. Arvanitakis Z, Schneider JA, Wilson RS et al. Diabetes is related to cerebral infarction but not to AD pathology in older persons. Neurology 2006; 67: 1960-1965. Go to original source... Go to PubMed...
    5. Beeri MS, Silverman JM, Davis KL et al. Type 2 diabetes is negatively associated with Alzheimer's disease neuropathology. J Gerontol A Biol Sci Med Sci 2005; 60: 471-475. Go to original source... Go to PubMed...
    6. Beeri MS, Schmeidler J, Silverman JM et al. Insulin in combination with other diabetes medication is associated with less Alzheimer neuropathology. Neurology 2008; 71: 750-757. Go to original source... Go to PubMed...
    7. Cukierman T, Gerstein HC, Williamson JD. Cognitive decline and dementia in diabetes - systematic overview of prospective observational studies. Diabetologia 2005; 48: 2460-2469. Go to original source... Go to PubMed...
    8. de la Monte SM, Tong M, Lester-Coll N et al. Therapeutic rescue of neurodegeneration in experimental type 3 diabetes: relevance to Alzheimer's disease. J Alzheimers Dis 2006; 10: 89-109. Go to original source... Go to PubMed...
    9. de la Monte SM. Insulin resistance and Alzheimer's disease. BMB Rep 2009; 42: 475-481. Go to original source... Go to PubMed...
    10. D'Ercole AJ, Ye P, Calikoglu AS et al. The role of the insulin-like growth factors in the central nervous system. Mol Neurobiol 1996; 13: 227-255. Go to original source... Go to PubMed...
    11. Gustavsson A, Svensson M, Jacobi F et al. CDBE2010Study Group. Cost of disorders of the brain in Europe 2010. Eur Neuropsychopharmacol 2011; 21: 718-779. Go to original source... Go to PubMed...
    12. Heitner J, Dickson D. Diabetics do not have increased Alzheimer-type pathology compared with age-matched control subjects. A retrospective postmortem immunocytochemical and histofluorescent study. Neurology 1997; 49: 1306-1311. Go to original source... Go to PubMed...
    13. Janson J, Laedtke T, Parisi JE et al. Increased risk of type 2 diabetes in Alzheimer disease. Diabetes 2004; 53: 474-481. Go to original source... Go to PubMed...
    14. Kumari M, Marmot M. Diabetes and cognitive function in a middle-aged cohort: findings from the Whitehall II study. Neurology 2005; 65: 1597-1603. Go to original source... Go to PubMed...
    15. Leibson CL, Rocca WA, Hanson VA et al. The risk of dementia among persons with diabetes mellitus: a population-based cohort study. Ann NY Acad Sci 1997; 826: 422-427. Go to original source... Go to PubMed...
    16. Ott A, Stolk RP, van Harskamp F et al. Diabetes mellitus and the risk of dementia: The Rotterdam Study. Neurology 1999; 53: 1937-1942. Go to original source... Go to PubMed...
    17. Rivera EJ, Goldin A, Fulmer N et al. Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: link to brain reductions in acetylcholine. J Alzheimers Dis 2005; 8: 247-268. Go to original source... Go to PubMed...
    18. Shaw JE, Sicree RA, Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract 2010; 87: 4-14. Go to original source... Go to PubMed...
    19. Schrijvers EM, Witteman JC, Sijbrands EJ et al. Insulin metabolism and the risk of Alzheimer disease: the Rotterdam Study. Neurology 2010; 75: 1982-1987. Go to original source... Go to PubMed...
    20. Schmidt R, Launer LJ, Nilsson LG et al. CASCADE Consortium. Magnetic resonance imaging of the brain in diabetes: the Cardiovascular Determinants of Dementia (CASCADE) Study. Diabetes 2004; 53: 687-692. Go to original source... Go to PubMed...
    21. Steen E, Terry BM, Rivera EJ et al. Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease - is this type 3 diabetes? J Alzheimers Dis 2005; 7: 63-80. Go to original source... Go to PubMed...
    22. Tůma I. Diabetes mellitus a kognitivní poruchy. Vnitř Lék 2007; 53: 486-488. Go to PubMed...
    23. Weber P. Diabetes mellitus - specifika a komplikace ve stáří. Interní Med 2008; 10: 456-460.
    24. Whitmer RA, Karter AJ, Yaffe K et al. Hypoglycemic Episodes and Risk of Dementia in Older Patients With Type 2 Diabetes Mellitus. JAMA 2009; 301: 1565-1572. Go to original source... Go to PubMed...
    25. Xu W, Qiu C, Gatz M et al. Mid- and late-life diabetes in relation to the risk of dementia: a population-based twin study. Diabetes 2009; 58: 71-77. Go to original source... Go to PubMed...
    26. Xu WL, von Strauss E, Qiu CX et al. Uncontrolled diabetes increases the risk of Alzheimer's disease: a population-based cohort study. Diabetologia 2009; 52: 1031-1039. Go to original source... Go to PubMed...
    27. Xu W, Caracciolo B, Wang HX et al. Accelerated progression from mild cognitive impairment to dementia in people with diabetes. Diabetes 2010; 59: 2928-2935. Go to original source... Go to PubMed...

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