Vnitr Lek 2011, 57(11):937-945

Genetics of monogenic forms of diabetes

J. Staník1,2, M. Hučková1, D. Staníková3, I. Mašindová1, L. Valentínová1, D. Gašperíková1,4, I. Klimeš1,4,*
1 DIABGENE & Laboratórium diabetu a porúch metabolizmu, Ústav experimentálnej endokrinológie SAV Bratislava, Slovenská republika, riaditeľ prof. MUDr. Iwar Klimeš, DrSc.
2 Detské diabetologické centrum SR pri I. detskej klinike LF UK a DFNsP Bratislava, Slovenská republika, prednostka doc. MUDr. Oľga Červeňová, CSc.
3 I. detská klinika LF UK a DFNsP Bratislava, Slovenská republika, prednostka doc. MUDr. Oľga Červeňová, CSc.
4 Molekulárno-medicínske centrum SAV Bratislava, Slovenská republika, riaditeľ MUDr. Richard Imrich, CSc.

Monogenic diabetes mellitus is a type of diabetes, where genetics without any other factors is strong enough to cause the disease. According to the clinical features monogenic diabetes can be divided to the mild familial early onset diabetes, familial fasting hyperglycemia, diabetes with extrapancreatic features and neonatal diabetes mellitus. During the last several years the number of genes causing monogenic diabetes has continuously increased. The clinical picture of the monogenic diabetes is very heterogeneous, thus DNA analysis is required for identification of the diabetes etiology, which influences also the choice of treatment. This article is an overview of current knowledge on monogenic diabetes, focusing at the clinically and epidemiologically most important forms.

Keywords: monogenic diabetes mellitus; MODY; neonatal diabetes; DNA analysis

Received: September 24, 2011; Published: November 1, 2011  Show citation

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Staník J, Hučková M, Staníková D, Mašindová I, Valentínová L, Gašperíková D, Klimeš I. Genetics of monogenic forms of diabetes. Vnitr Lek. 2011;57(11):937-945.
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