Vnitr Lek 2011, 57(4):417-421

Incretin therapy and the metabolic syndrome

Š. Svačina

III. interní klinika 1. lékařské fakulty UK a VFN Praha, přednosta prof. MUDr. Štěpán Svačina, DrSc., MBA

Incretin therapy includes treatment with incretin analogues (exenatid and liraglutid) and so called incretin enhancers (gliptins and DPP-4 inhibitors respectively - sitagliptin, vildagliptin, saxagliptin, linagliptin). In patients with type 2 diabetes, this novel antidiabetic treatment usually leads to successful reduction in fasting as well as postprandial glycaemia and glycosylated haemoglobin. At the same time, it importantly improves all components of metabolic syndrome (dyslipidemia, hypertension, systemic inflammation). Incretin analogues also reduce body weight while DPP-4 inhibitors are weight-neutral. Both groups of drugs are expected to have positive cardiovascular effects, although it is not clear whether these are likely to be direct or indirect, i.e. facilitated by improved compensation of metabolic syndrome components.

Keywords: type 2 diabetes mellitus; incretin analogues; gliptins; exenatid; liraglutid; sitagliptin; vildagliptin; saxagliptin; linagliptin; obesity; metabolit syndrome

Received: February 13, 2011; Published: April 1, 2011  Show citation