Vnitr Lek 2011, 57(4):351-355

Motility disorders and gastric emptying in diabetes mellitus. Current diagnostics and treatment

J. Bureš1,2,*, A. Šmahelová3,4, I. Tachecí1,2, S. Rejchrt1,2, M. Kopáčová1,2
1 II. interní klinika Lékařské fakulty UK a FN Hradec Králové, přednosta prof. MUDr. Jaroslav Malý, CSc.
2 Subkatedra gastroenterologie Lékařské fakulty UK Hradec Králové, vedoucí prof. MUDr. Jan Bureš, CSc.
3 Klinika gerontologická a metabolická Lékařské fakulty UK a FN Hradec Králové, přednosta prof. MUDr. Luboš Sobotka, CSc.
4 Subkatedra diabetologie Lékařské fakulty UK Hradec Králové, vedoucí doc. MUDr. Alena Šmahelová, Ph.D.

Autonomic neuropathy of the gastrointestinal tract is a common complication of diabetes mellitus. However, it is seldom recognised properly as it is rarely considered. In some patients, it might be asymptomatic or hardly compensatable diabetes can be the only one sign. There are non-invasive diagnostic methods to assess gastric emptying rate (13C-octanoic acid breath test) or myoelectric activity of the stomach (electrogastrography). The principle treatment comprises optimal control of diabetes and use of prokinetics.

Keywords: diabetes mellitus; motor disorder; gastroparesis; gastric emptying rate; electrogastrography

Received: February 28, 2011; Published: April 1, 2011  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Bureš J, Šmahelová A, Tachecí I, Rejchrt S, Kopáčová M. Motility disorders and gastric emptying in diabetes mellitus. Current diagnostics and treatment. Vnitr Lek. 2011;57(4):351-355.
Download citation

References

  1. Frieling T. Diabetic autonomic neuropathy of the gastrointestinal tract. UpToDate [on line]. 18. 3. Wellesley, 2010. http://www.uptodate.com/contents/diabetic-autonomic-neuropathy-of-the-gastrointestinal-tract?source=search_result&selectedTitle=1%7E150.
  2. Sfarti C, Trifan A, Hutanasu C et al. Prevalence of gastroparesis in type 1 diabetes mellitus and its relationship to dyspeptic symptoms. J Gastrointestin Liver Dis 2010; 19: 279-284.
  3. Šmahelová A. Akutní komplikace diabetu. Praha: Triton 2008.
  4. Šmahelová A. Akutní komplikace diabetu a trávicí trakt. Vnitř Lék 2004; 50: 404-407. Go to PubMed...
  5. Rejchrt S, Koupil I, Kopáčová M et al. European Society for Primary Care Gastroenterology. Prevalence and sociodemographic determinants of uninvestigated dyspepsia in the Czech Republic. Eur J Gastroenterol Hepatol 2008; 20: 898-905. Go to original source... Go to PubMed...
  6. Bureš J, Kopáčová M, Koupil I et al. European Society for Primary Care Gastroenterology. Epidemiology of Helicobacter pylori infection in the Czech Republic. Helicobacter 2006; 11: 56-65. Go to original source... Go to PubMed...
  7. Kopáčová M, Bureš J, Koupil I et al. Body indices and basic vital signs in Helicobacter pylori positive and negative persons. Eur J Epidemiol 2007; 22: 67-75. Go to original source... Go to PubMed...
  8. Bureš J, Šmahelová A, Kopáčová M et al. Klinický význam infekce Helicobacter pylori u nemocných s diabetes mellitus. Vnitř Lék 2004; 50: 350-353. Go to PubMed...
  9. Gumaste VV, Egbuna I, Goldman A. Diabetes is not an independent predictor of gastroparesis in symptomatic patients referred for gastric emptying studies. J Gastrointest Liver Dis 2010; 19: 37-42.
  10. Bureš J, Kopáčová M, Voříšek V et al. Stanovení rychlosti evakuace žaludku pomocí dechového testu s 13C-oktanovou kyselinou. Metodika testu pro dospělé a výsledky vyšetření zdravých dobrovolníků. Čas Lék Čes 2005; 144 (Suppl 3): 18-22.
  11. Bureš J, Kopáčová M, Voříšek V et al. Correlation of electrogastrography and gastric emptying rate estimated by 13C-octanoic acid breath test in healthy volunteers. Folia Gastroenterol Hepatol 2007; 5: 5-11.
  12. Rejchrt S, Kopáčová M, Koupil I et al. Delta values of the 13C-urea breath test in Helicobacter pylori positive persons with and without dyspepsia. Folia Gastroenterol Hepatol 2004; 2: 105-110.
  13. Chang J, Rayner CK, Jones KL et al. Diabetic gastroparesis and its impact on glycemia. Endocrinol Metab Clin North Am 2010; 39: 745-762. Go to original source... Go to PubMed...
  14. Janssen P, Vanden Berghe P et al. Review article: the role of gastric motility in the control of food intake. Aliment Pharmacol Ther 2011; 33: 880-894. Go to original source... Go to PubMed...
  15. Reddy S, Ramsubeik K, Vega KJ et al. Do HbA1c Levels Correlate With Delayed Gastric Emptying in Diabetic Patients? J Neurogastroenterol Motil 2010; 16: 414-417. Go to original source... Go to PubMed...
  16. Camilleri M. Pathogenesis of delayed gastric emptying. UpToDate [on line]. 18. 3. Wellesley, 2010. http://www.uptodate.com/contents/pathogenesis-of-delayed-gastric-emptying?source=search_result&selectedTitle=1%7E76.
  17. Kojecký V. Dysmotilita horní části zažívacího traktu u diabetu. Med praxi 2007; 6: 259-261.
  18. Kojecký V, Bernatek J, Horowitz M et al. Prevalence and determinants of delayed gastric emptying in hospitalised type 2 diabetic patients. World J Gastroenterol 2008; 14: 1564-1569. Go to original source... Go to PubMed...
  19. Lacigová S, Rušavý Z, Mindlová J et al. Žaludeční vyprazdňování u diabetiků. Vnitř Lék 2000; 46: 213-217. Go to PubMed...
  20. Samsom M, Bharucha A, Gerich JE et al. Diabetes mellitus and gastric emptying: questions and issues in clinical practice. Diabetes Metab Res Rev 2009; 25: 502-514. Go to original source... Go to PubMed...
  21. Bureš J, Cyrany J, Kohoutová D et al. Small intestinal bacterial overgrowth syndrome. World J Gastroenterol 2010; 16: 2978-2990. Go to original source... Go to PubMed...
  22. Reddymasu SC, McCallum RW. Small intestinal bacterial overgrowth in gastroparesis: are there any predictors? J Clin Gastroenterol 2010; 44: e8-e13. Go to original source... Go to PubMed...
  23. Bureš J. Léčba gastroparézy. Folia Gastroenterol Hepatol 2007; 5: 44-46.
  24. Chang J, Rayner CK, Jones KL et al. Diabetic gastroparesis - backwards and forwards. J Gastroenterol Hepatol 2011; 26 (Suppl 1): 46-57. Go to original source... Go to PubMed...
  25. Hata N, Murata S, Maeda J et al. Predictors of gastric myoelectrical activity in type 2 diabetes mellitus. J Clin Gastroenterol 2009; 43: 429-436. Go to original source... Go to PubMed...
  26. Stevens JE, Gilja OH, Gentilcore D et al. Measurement of gastric emptying of a high-nutrient liquid by 3D ultrasonography in diabetic gastroparesis. Neurogastroenterol Motil 2011; 23: e220-e224. Go to original source... Go to PubMed...
  27. Parkman HP, Fass R, Foxx-Orenstein AE. Treatment of patients with diabetic gastroparesis. Gastroenterol Hepatol 2010; 6: 1-16.
  28. Sanaka M, Yamamoto T, Kuyama Y. Effects of proton pump inhibitors on gastric emptying: a systematic review. Dig Dis Sci 2010; 55: 2431-2440. Go to original source... Go to PubMed...
  29. Kojecký V, Bernátek J, Bakala J et al. Vliv itopridu na rychlost a průběh evakuace žaludku diabetiků a jejich vztah ke kompenzaci diabetu. Čes Slov Gastroenterol Hepatol 2005; 59: 17-20.
  30. McCallum RW, Snape W, Brody F et al. Gastric electrical stimulation with Enterra therapy improves symptoms from diabetic gastroparesis in a prospective study. Clin Gastroenterol Hepatol 2010; 8: 947-954. Go to original source... Go to PubMed...




Vnitřní lékařství

Madam, Sir,
please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

I declare:

  1. that I have met the above instruction
  2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited


No

Yes

If your statement is not true, please be aware
that brings the risk of danger to their health or the health of others.