Vnitr Lek 2010, 56(6):620-623
Changes in lipoprotein spectrum in patients with the diagnosis of extremito-vascular ischemic disease
- II. interná klinika Lekárskej fakulty UK Bratislava, Slovenská republika, prednosta prof. MUDr. Andrej Dukát, CSc., FESC
New method of lipoprotein determination on polyacrylamid gel with Lipoprint LDL system quantifies non atherogenic and atherogenic plasma lipoproteins, including small dense LDL, the potent atherogenic lipoprotein subpopulations. According to majority of non atherogenic versus atherogenic lipoprotein in the whole lipoprotein spectrum, this method distinguishes a non atherogenic lipoprotein profile phenotype A from an atherogenic lipoprotein profile phenotype B. Definitely, the contribution of this method is focusing on the atherogenic lipoprotein profile phenotype B in 80% of patients with an extremito-vascular ischemic disease and on the existence of control subgroup of normolipemic subjects with an atherogenic lipoprotein profile (7% of probands of control group). These persons represent a risk population. Till now, the facilities for identifying of these "normolipemic persons at risk" are limited.
Keywords: atherogenic lipoproteins; atherogenic vs non atherogenic lipoprotein profile
Received: May 31, 2010; Published: June 1, 2010 Show citation
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