Vnitr Lek 2010, 56(6):607-612

The value of baroreflex sensitivity for cardiovascular risk stratification in hypertensives

D. Čelovská1,*, J. Staško2, J. Gonsorčík3, A. Dukát1
1 II. interná klinika Lekárskej fakulty UK a FNsP Bratislava, Slovenská republika, prednosta prof. MUDr. Andrej Dukát CSc., FESC
2 Klinika kardiológie FNsP J. A. Reimana Prešov, Slovenská republika, prednosta doc. MUDr. Alexander Kiško, CSc.
3 Klinika kardiológie Lekárskej fakulty UPJŠ a VÚSCH Košice, Slovenská republika, prednosta MUDr. Branislav Stančák, CSc.

Impaired baroreflex sensitivity (BRS) is a marker of autonomous dysfunction, which may play an important role in the long-term development of arterial hypertension, disease progression as well as complications related to global cardiovascular risk. The aim of the study was to evaluate the clinical significance of baroreflex sensitivity in hypertensives with/without major cardiovascular events. We found out that essential hypertension is associated with decreased BRS, and that grade of hypertension is inversely related to BRS values. Spontaneous BRS values in hypertensives with major cardiovascular event (stroke, myocardial infarction) were significantly lower even 6 months and more after myocardial infarction and stroke onset compared to remaining patients (p < 0.05). BRS is a clinically applicable, noninvasive method for assessing early dysfunction of autonomic nervous system, which seems to be an additive emerging marker of cardiovascular risk stratification in hypertensive patients.

Keywords: baroreflex sensitivity; autonomic nervous system; arterial hypertension; stroke; myocardial infarction

Received: May 29, 2010; Published: June 1, 2010  Show citation

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Čelovská D, Staško J, Gonsorčík J, Dukát A. The value of baroreflex sensitivity for cardiovascular risk stratification in hypertensives. Vnitr Lek. 2010;56(6):607-612.
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