Vnitr Lek 2010, 56(1):49-52

Paraneoplastic thromboembolic syndrome as the first sign of a malignant disease

M. Žuffa
Interné oddelenie Liptovskej nemocnice s poliklinikou Liptovský Mikuláš, Slovenská republika, prednosta prim. MUDr. Viliam Iľanovský

We describe the paraneoplastic thromboembolic syndrome in venous and arterial (coronary, cerebral, peripheral) systems and in the heart (paraneoplastic endocarditis). We emphasise that the syndrome may signal presence of an occult malignant disease that, at that time, might be treatable.

Keywords: paraneoplastic thromboembolic syndrome; early diagnosis of malignant diseases

Received: May 13, 2009; Accepted: October 12, 2009; Published: January 1, 2010  Show citation

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Žuffa M. Paraneoplastic thromboembolic syndrome as the first sign of a malignant disease. Vnitr Lek. 2010;56(1):49-52.
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    References

    1. Miller S, Sanches-Avalos J, Stefanski T et al. Coagulation disorders in cancer. Clinic and laboratory study. Cancer 1967; 20: 1452. Go to original source... Go to PubMed...
    2. Žuffa M, Kubančok J, Rusnák I et al. Early paraneoplastic syndrome in medical oncology: Clinico-pathological analysis 1,694 patients treated over 20 years. Neoplasma 1984; 31: 231. Go to PubMed...
    3. Žuffa M, Kubančok J, Horváth A. The thromboembolic disease as paraneoplastic syndrome. Neoplasma 1982; 29: 241. Go to PubMed...
    4. Edwards E. Migratory thrombophlebitis associated with carcinoma. N Engl J Med 1949; 240: 1131. Go to original source... Go to PubMed...
    5. Wessler S, Iin ET. The experimental hypercoagulable state induced by factor X. Lab Clin Med 1944; 108: 344.
    6. Oster WM. Thrombophlebitis and cancer. Angiology 1976; 27: 577. Go to original source... Go to PubMed...
    7. Lisker SA, Finkelstein D, Brody J et al. Myocardial infarction in acute leukemia: Report of case in a young man. Arch Intern Med 1967; 119: 768. Go to original source...
    8. Sharma S, Marini D. Acute myocardial infarction with chronic myelogenous leukemia. Ann Hematol 1996; 72: 152. Go to original source... Go to PubMed...
    9. Jachmann-Jahn U, Comelly OH, Laufs U et al. Acute anterior myocardial infarction as a first manifestation acute myeloid leukemia. Ann Hematol 2001; 80: 677. Go to original source... Go to PubMed...
    10. Lou Y, Mai W, Jin J. Simultaneous presentation and acute promyelocytic leukemia Ann Hematol 2006; 85: 409. Go to original source... Go to PubMed...
    11. Ogawa A, Kanda T, Sugihara S et al. Risk factor of myocardial infarction in cancer patients. J Med 1995; 25: 221.
    12. Chinen K, Kurosumi M, Ohkura Y et al. Sudden unespected death in patient with malignancy: clinicopathological study of 28 autopsy cases. Pathol Res Pract 2006; 202: 869. Go to original source... Go to PubMed...
    13. Minai FN, Monen A. Paraneoplastic syndrome of renal carcinoma. J Coll Phys Sus Pak 2006; 16: 81.
    14. Lindhal HK, Sendset PM, Abildagaard D. Indices hypercoagulation in cancer as compared with those acute inflamation and acute infarction. Haemostasis 1990; 20: 253. Go to original source... Go to PubMed...
    15. Ramiszewski P, Slodkowska J, Czepek P. Zawal miesnia sercovega ako pryczyna chorych leczonnych z powodu drobnokomorkowiego raka pluca. Pneumol Alergol Pol 1999; 67: 62.
    16. Nashitz JE, Yeshurn D, Abrahamson J. Ischemic heart disease precipitated by occult cancer. Cancer 1992; 69: 2712. Go to original source... Go to PubMed...
    17. Sengoku S, Sengoku K, Kohn J et al. Four cases noncardiac surgery after PTCA. Masui 1995; 40: 253.
    18. Hobbson AR, McKenzie DP, Kunadian VP et al. Malignancy: an unrecognosided risk factor for coronary stent thrombosis. J Invasion Cardiol 2008; 20: E120.
    19. Žuffa M, Devečka D, Rusnák I et al. Myocardial infarction paraneoplastically facilitated? Bratisl Lek Lis 2005; 160: 324.
    20. Hickey WF, Garnick MB, Henderson IC et al. Primary cerebral venous thrombosis in patients with cancer - a rarely paraneoplastic syndrome. Report of tree cases and review of the literature. Am J Med 1982; 18: 94.
    21. Žuffa M, Moyš A, Ujcová B. Ischemická cievna príhoda mozgová paraneoplasticky facilitovaná? Slov Lek 2008; 18: 94.
    22. Igegushi H, Ono S, Ueda A et al. Catastrophic antiphosfolipid syndrome associated with malignancies. Lupus 2007; 15: 59. Go to original source...
    23. Taccome PS, Jeanquette SM, Blecie SA. First ever stroke as initial presentation of systemic cancer. J Stroke Cerebrovasc Dis 2008; 17: 169 Go to original source... Go to PubMed...
    24. Reggerone S, Traverse-Glehen A, Derex L. Recurrent cerebral venous thrombosis revealing paraneoplastic angiitis in Hodgkin lymphoma. J Neurooncol 2008; 89: 195. Go to original source... Go to PubMed...
    25. Stefan O, Verra N, Otto B et al. Stroke in cancer patients: a risk factor analysis. J Neurooncol 2009; 25: 12. Go to original source... Go to PubMed...
    26. Friedman SA, Biennstock H, Richter IH. Malignancy and arteriopathy. Angiology 1969; 20: 136. Go to original source... Go to PubMed...
    27. Push JH, Koch W, Wegener W et al. Paraneoplastische Syndrome in innere Medizin. Med Welt 1976; 27: 2372.
    28. Naschitz JE, Yesthurun D, Abrahamson J. Arterial occlusive disease in cancer. Am Heart J 1992; 124: 738. Go to original source... Go to PubMed...
    29. Aboyans W, Lacroix P, Cornu E et al. Paraneoplastic arterial thrombosis: a propos 2 cases. Arch Mal Coeur Vaiss 1996; 86. 1297.
    30. Zakraoui H, Fenische S, Chekils S et al. Paraneoplastic digital necrosis: a case report. Tunis Med 2007; 85: 532. Go to PubMed...
    31. Adams R. Case report of the Massachusetts General Hospital. N Engl J Med 1955; 253: 1030. Go to original source...
    32. Nagano N, Morin FJ, Joyal D et al. Acute myocardial infarction and limb ischemia as a manifestation of nonbacterial thrombotic endocarditis. J Thorac Cardiovasc Surg 2009; 137: 1278. Go to original source... Go to PubMed...
    33. Frazer G, Laing R, Lamont D. Non-bacterial thrombotic endocarditis with negative transesophageal echocardiogram. N Z Med J 2005; 1018: U1589.
    34. Žuffa M, Kubančok J, Kučerová B et al. Embolizing paraneoplastic endocarditis as a first manifestation an occult malignoma (a case report). Neoplasma 1969; 16: 451. Go to PubMed...
    35. Žuffa M, Kubančok J, Burda K. Náhla príhoda brušná ako prvý príznak okultného maligného nádoru s embolizujúcou paraneoplastickou endokarditídou. Vnitř Lék 1970; 24: 393.
    36. Messerschmidt I, Kubančok J, Žuffa M. Cerebrálna embolizácia pri okultnom malignóme žalúdka s paraneoplastickou endokarditídou. Cs Neurol 1972; 35: 213.
    37. Žuffa M, Kubančok J, Dúbravka M. Embolizing paraneoplastic endocarditis with lethal myocardial infarction (description of a case). Neoplasma 1970; 17: 565. Go to PubMed...
    38. Laco J, Steiner I, Havel E. Non bacterial thrombotic endocarditis involving all four cardiac valves. Pathol Res Pract 2008; 204: 757. Go to original source... Go to PubMed...
    39. Allen AC, Sirota JR. The morphogenesis and significance of degenerative verrucal endocarditis (terminal endocarditis, endocarditis simplex, nonbacterial thrombotic endocarditis). Am J Path 1944; 20: 1025.
    40. Horváth A, Žuffa M, Lehotský E. Embolizujúce trombotické nebakteriálne endokarditídy pri karcinómoch pankreasu. Bratisl Lek Lis 1966; 47: 196. Go to original source...
    41. Žuffa M, Kubančok J, Horváth A. Paraneoplastic endocarditis. Neoplasma 1972; 19: 141. Go to PubMed...
    42. Žuffa M. Výskyt paraneoplastickej endokarditídy. Bratisl Lek Lis 1970; 54: 45.
    43. Schubertová J. Žilní trombóza jako první příznak skrytého asymptomatického zhoubného onemocnění. Cas Lek Ces 1969; 108: 117.
    44. Hrubišková K. Poruchy hemokoagulácie a hemostázy. Martin: Osveta, s. 92.
    45. Ondriaš F, Slugeň I, Valach A. Malignant tumours and embolizing paraneoplastic endocarditis. Neoplasma 1985; 32: 135. Go to PubMed...
    46. Hromec A, Okrucká A. Zmeny v hemostáze ako jedna z paraneoplastických prejavov. Bratisl Lek Lis 1988; 89: 577. Go to original source...
    47. Klabusay L. Klinický význam paraneoplastického syndrómu. Vnitř Lék 1989; 35: 237. Go to PubMed...
    48. Opat P. Biologické aspekty paraneoplastických syndrómů. Vnitř Lék 1991; 37: 810. Go to PubMed...
    49. Karetová D. Trombotické komplikace u pacientů se zhoubními nemocemi. Vnitř Lék 2000; 46: 715. Go to PubMed...
    50. Malý J, Blažek M, Bláha M et al. Změny hemostázy u maligních onemocnění. Vnitř Lék 2002; 48: 614. Go to PubMed...
    51. Steiner I. Nebakteriání trombotická endokarditis - studium 171 případů. Cesk Patol 1993; 29: 58. Go to PubMed...
    52. Adam Z, Chalupová C, Tomášek J et al. Systémové a paraneoplastické projevy zhoubních onemocnění. Vnitř Lék 2007; 53: 284.

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