Vnitr Lek 2009, 55(9):841-844
AT1-blockers in the treatment of hypertension
- Centrum pro hypertenzi III. interní kliniky 1. lékařské fakulty UK a VFN Praha, přednosta prof. MUDr. Štěpán Svačina, DrSc., MBA
Angiotensin receptor antagonists (AT1-blockers) are considered as one of the major classes of antihypertensive drugs suitable for monotherapy as well as for combination treatment. Mechanisms of antihypertensive effects of AT1-blockers are discussed altogether with the results of large clinical trials and indication in hypertension.
Keywords: AT1-blockers; hypertension; treatment
Received: June 29, 2009; Published: September 1, 2009 Show citation
References
- Kaplan N. Clinical Hypertension. Philadelphia: Lippincott Williams & Wilkins 2006.
- Healey JS, Baranchuk A, Crystal E et al. Prevention of atrial fibrillation with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: a meta-analysis. J Am Coll Cardiol 2005; 45: 1832-1839.
Go to original source...
- Cheng JW. Aliskiren: renin inhibitor for hypertension management. Clin Ther 2008; 30: 31-47.
Go to original source...
Go to PubMed...
- Widimský J jr, Cífková R, Špinar J et al. Doporučení diagnostických a léčebných postupů u arteriální hypertenze - verze 2007. Doporučení České společnosti pro hypertenzi. Cor Vasa 2008; 50: K3-K16.
- Weber MA. Angiotensin receptor blockers. In: Izzo JL, Sica DA, Black HR et al (eds). Hypertension primer. Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins 2008: 461-464.
- De Gasparo M, McInnes GT. Angiotensin receptor blockers. In: McInnes (ed). Clinical Pharmacology and Therapeutics of hypertension. Amsterdam: Elsevier 2008: 339-374.
- Dahlhöf B, Devereux RB, Kjeldsen SE et al. LIFE study group. Cardiovascular morbidity and mortality in the Losartan intervention for End point reduction in hypertension study (LIFE): a randomised trial against atenolol. Lancet 2002; 359: 995-1003.
Go to original source...
Go to PubMed...
- Julius S, Kjeldsen SE, Weber M et al. VALUE trial group. Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial. Lancet 2004; 363: 2022-2031.
Go to original source...
Go to PubMed...
- Brenner BM, Cooper ME, de Zeeuw D et al. RENAAL Study. Effects of losartan on renal and cardiovascular outcomes in patients with type-2 diabetes and nephropathy. N Engl J Med 2001; 345: 861-869.
Go to original source...
Go to PubMed...
- Pohl MA, Blumenthal S, Cordonnier DJ et al. Independent and additive impact of blood pressure control and angiotensin II receptor blockade on renal outcomes in the irbesartan diabetic nephropathy trial: clinical implications and limitations. J Am Soc Nephrol 2005; 16: 3027-3037.
Go to original source...
Go to PubMed...
- Parving HH, Lehnert H, Bröchner-Mortensen J et al. The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes. N Engl J Med 2001; 345: 870-878.
Go to original source...
Go to PubMed...
- Schrader J, Lüders S, Kulschewski A et al. MOSES Study Group. Morbidity and Mortality After Stroke. Eprosartan Compared with Nitrendipine for Secondary Prevention: principal results of a prospective randomized controlled study (MOSES). Stroke 2005; 36: 1218-1226.
Go to original source...
Go to PubMed...
- Lithell H, Hansson L, Skoog I et al. SCOPE Study Group. The Study on Cognition and Prognosis in the Elderly (SCOPE). Principal results of a randomized double-blind intervention trial. J Hypertens 2003; 21: 875-886.
Go to original source...
Go to PubMed...
- Yusuf S, Teo KK, Pogue J et al. ONTARGET Investigators. Telmisartan, ramipril, or both in patients at high risk for vascular events. N Engl J Med 2008; 358: 1547-1559.
Go to original source...
Go to PubMed...
- Conlin PR, Spence JD, Wiliams B et al. Angiotensin II antagonists for hypertension: are there differences in efficacy? Am J Hypertens 2000; 13: 418-426.
Go to original source...
Go to PubMed...
- Fabia MJ, Abdilla N, Oltra R et al. Antihypertensive activity of angiotensin II AT1 receptor antagonists: a systematic review of studies with 24 h ambulatory blood pressure monitoring. J Hypertens 2007; 25: 1327-1336.
Go to original source...
Go to PubMed...
- Krupička J, Ceypová K, Kristenová P et al. Bezpečnost dlouhodobého podávání losartanu v běžné klinické praxi: neintervenční studie NCT-CZ 14/04/LOZ. Vnitř Lék 2008; 54: 1031-1038.
Go to PubMed...