Vnitr Lek 2008, 54(11):1100-1101

Hypoglycaemic periodic paralysis in hyperthyroidism patients

J. Kratochvíl^*, J. Masopust, V. Martínková, J. Charvát

Jednotka intenzivní metabolické péče Interní kliniky 2. lékařské fakulty UK a FN Motol Praha, přednosta prof. MUDr. Milan Kvapil, CSc., MBA

Hypokalemic periodic paralysis (HPP) is a rare disorder characterised by acute, potentially fatal atacks of muscle weakness or paralysis. Massive shift of potassium into cells is caused by elevated levels of insulin and catecholamines in the blood. Hypophosphatemia and hypomagnesemia may be also present. Acidobasic status usually is not impaired. HPP occurs as familiar (caused by ion channels inherited defects) or acquired (in patients with hyperthyroidism). On the basis of two clinical cases we present a review of hypokalemic periodic paralysis in hyperthyroid patients. We discuss patogenesis, clinical and laboratory findings as well as the principles of prevention and treatment of this rare disorder.

Keywords: hyperthyroidism; hypokalemia; hypokalemic periodic paralysis

Received: February 21, 2008; Accepted: July 8, 2008; Published: November 1, 2008  Show citation