Vnitr Lek 2006, 52(10):935-940

Mechanisms of the intracellular activities of thyroid gland hormones

J. Brtko
Laboratórium molekulárnej endokrinológie, Ústav experimentálnej endokrinológie SAV, Bratislava, Slovenská republika, riaditeľ MUDr. Vladimír Štrbák, DrSc.

Function of thyroid hormones affecting broad spectrum of various biochemical and molecular biology reactions in organisms is unimaginable without fully functional nuclear receptors. On account of this fact, research on the role and function of thyroid hormone receptors that play a role as thyroid hormone inducible transcription factors, belongs to dynamically developing branches of molecular endocrinology. In organism, full functionality of thyroid hormone receptors in the form of heterodimer with nuclear 9-cis retinoic acid receptor is essential for biological effects of 3,5,3'-triiodothyronine.

Keywords: L-thyroxine; iodothyronine deiodinase; 3,5,3’-triiodothyronine; nuclear receptor; 9-cis retinoic acid; molecular mechanism of thyroid hormones action

Received: June 20, 2006; Published: October 1, 2006  Show citation

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Brtko J. Mechanisms of the intracellular activities of thyroid gland hormones. Vnitr Lek. 2006;52(10):935-940.
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