Vnitr Lek 2006, 52(6):628-631

Nuclear receptors PPARα

V. Soška
Centrum pro diagnostiku a léčbu dyslipidemií, Oddělení klinického komplementu FN u sv. Anny, Brno, přednosta doc. MUDr. Vladimír Soška, CSc.

Mechanism of the fibrates action is mediated by nuclear PPARα receptors (Peroxisome Proliferator-Activated Receptor). These receptors regulate a number of genes that are involved both in lipids and lipoproteins metabolism and other mediators (e.g. inflammatory mediatores). Due to PPARα activation by fibrates, triglycerides and small dense LDL concentration is decreased, HDL cholesterol is increased and both inflammation and prothrombotic status are reduced. These effects are very important in patients with metabolic syndrom.

Keywords: nuclear receptors PPARα; fibrates; statins; metabolic syndrom

Received: November 15, 2005; Accepted: February 12, 2006; Published: June 1, 2006  Show citation

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Soška V. Nuclear receptors PPARα. Vnitr Lek. 2006;52(6):628-631.
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