Vnitr Lek 2006, 52(5):446-450

Pathogenesis of the connective tissue in diabetes

J. Škrha
III. interní klinika 1. lékařské fakulty UK a VFN, Praha, přednosta prof. MUDr. Štěpán Svačina, DrSc., MBA

Non-enzymatic glycation and oxidative stress are main contributors in pathogenesis of the connective tissue changes in diabetes. Properties of separate parts in the connective tissue and particularly those of intercellular matrix may be impaired by both mechanisms. In addition, changes in microcirculation including endothelial dysfunction and also diabetic neuropathy further aggravate tissue impairment. Despite known pathogenic mechanisms in development of diabetic microangiopathy there are series of unresolved questions in the pathogenesis of diabetic skin disorders.

Keywords: diabetes mellitus; connective tissue; protein glycation; oxidative stress

Received: June 3, 2005; Accepted: June 3, 2005; Published: May 1, 2006  Show citation

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Škrha J. Pathogenesis of the connective tissue in diabetes. Vnitr Lek. 2006;52(5):446-450.
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    References

    1. Rask-Madsen Ch, He Z, King GL. Mechanisms of diabetic microvascular complications. In: Kahn CR (ed). Joslin's Diabetes mellitus. 14th ed. Philadelphia: Lippincott Williams & Wilkins 2005: 823-838.
    2. Brownlee M. Advanced glycation end products in diabetic complications. Curr Opin Endocrinol Diabetes 1998; 3: 291-297. Go to original source...
    3. Reihsner R., Meilling M, Pfeiler W et al. Alterations of biochemical and two-dimensional biomechanical properties of human skin in diabetes mellitus as compared to effects of in vitro non-enzymatic glycation. Clin Biomechanics 2000; 15: 379-386. Go to original source... Go to PubMed...
    4. Schleicher E, Nerlich A. The role of hyperglycemia in the development of diabetic complications. Horm Metab Rev 1996; 28: 367-373. Go to original source... Go to PubMed...
    5. Delbridge L, Ellis CS, Robertson K et al. Non-enzymatic glycosylation of keratin from the stratum corneum of the diabetic foot. Brit J Dermatol 1985; 112: 547-554. Go to original source... Go to PubMed...
    6. Sehnalová H, Záhejský J. Sledování neenzymatické glykace epidermálního keratinu. Čs Dermatol 1991; 66: 25-30. Go to original source...
    7. Sehnalová H, Záhejský J. Charakteristika glykované bílkoviny keratinu. Čs Dermatol 1992; 67: 29-33.
    8. Lateef H, Stevens MJ, Varani J. Alltrans-retinoic acid suppresses matrix metalloproteinase activity and increases collagen synthesis in diabetic human skin in organ culture. Am J Pathol 2004; 165: 167-174. Go to original source... Go to PubMed...
    9. Ceriello A, Dello Russo P, Curcio F et al. Acetylsalicylic acid and lysine inhibit protein glycosylation in vitro. Diabetes Metabolism 1984; 10: 128-129.
    10. Ortwerth BJ, Olesen PR. Glutathione inhibits the glycation and cross-linking of lens protein by ascorbic acid. Exp Eye Res 1988; 47: 737-740. Go to original source... Go to PubMed...
    11. Khatani M, Suldan Z, David D et al. Inhibitory effects of pyridoxal phosphate, ascorbate and aminoguanidine on nonenzymatic glycosylation. Life Sci 1988; 43: 1725-1731. Go to original source... Go to PubMed...
    12. Škrha J. Oxidační stres a diabetes mellitus. In: Perušičová J (ed). Trendy soudobé diabetologie. Praha: Galén 1998; 1: 61-88.
    13. Ceriello A, dello Russo P, Amstad P et al. High glucose induces antioxidant enzymes in human endothelial cells in culture. Diabetes 1996; 45: 471-477. Go to original source... Go to PubMed...
    14. Sharpe PC, Liu WH, Yue KKM et al. Glucose-induced oxidative stress in vascular contractile cells. Diabetes 1998; 47: 801-809. Go to original source... Go to PubMed...
    15. Kawamura N, Ookawara T, Suzuki K et al. Increased glycated Cu,Zn-superoxide dismutase levels in erythrocytes of patients with insulin-dependent diabetes mellitus. J Clin Endocrinol Metab 1992; 74: 1352-1354. Go to original source...
    16. Kilanczyk E, Bryszewska M. The effect of melatonin on antioxidant enzymes in human diabetic skin fibroblasts. Cell & Molec Biol Lett 2003; 8: 333-336.
    17. Tesfamariam B, Cohen RA. Free radicals mediate endothelial cell dysfunction caused by elevated glucose. Am J Physiol 1992; 263: H321-H326. Go to original source... Go to PubMed...
    18. Nakai K, Kubota Y, Kosaka H. Inhibition of nuclear factor kappa B activation and inducible nitric oxide synthase transcription by prolonged exposure to high glucose in the human keratinocyte cell line HaCaT. Brit J Dermatol 2004; 150: 640-646. Go to original source... Go to PubMed...
    19. Chang CH, Tsai RK, Wu WC et al. Use of dynamic capillaroscopy for studying cutaneus microcirculation in patients with diabetes mellitus. Microvasc Res 1997; 53: 121-127. Go to original source... Go to PubMed...
    20. Prázný M. Využití laser Doppleru při vyšetření tkáňové perfuze. Diabetologie, metabolismus, endokrinologie, výživa 2000; 3: 111-116.
    21. Škrha J. Patofyziologie a patogeneze diabetické neuropatie. Vnitř Lék 2005; 51(Suppl 1): S67-S72.

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