Vnitr Lek 2005, 51(11):1289-1296

New possibilities in the treatment of chronic thromboembolic pulmonary hypertension

M. Škvařilová1,*, P. Jansa1, J. Lindner2, J. Kunstýř3, E. Mayer4, S. Heller1, T. Paleček1, M. Aschermann1, J. Tošovský2
1 II. interní klinika kardiologie a angiologie 1. lékařské fakulty UK a VFN Praha, přednosta prof. MUDr. Michal Aschermann, DrSc., FESC
2 II. chirurgická klinika kardiovaskulární chirurgie 1. lékařské fakulty UK a VFN, Praha, přednosta doc. MUDr. Jan Tošovský, CSc.
3 Klinika anesteziologie a resuscitace 1. lékařské fakulty UK a VFN, Praha, přednosta MUDr. Martin Stříteský, CSc.
4 Klinik für Herz-, Torax- und Gefäßchirurgie, Johanes Gutenberg Universität Mainz, Německo, direktor prof. Dr. Med. Christian-F. Vahl

Pulmonary arterial hypertension (PAH) has a multifactorial pathobiology. Vasoconstriction, remodeling of the pulmonary vessel wall, and thrombosis contribute to increased pulmonary vascular resistance in PAH. Prostanoids have played a prominent role in the treatment of PAH. They improves exercise capacity, hemodynamics, and survival in patients with idiopathic pulmonary arterial hypertension (IPAH). Several interventional and surgical approaches are available for treatment of PAH - atrial septostomy, lung or heart-lung transplantation. Pulmonary endarterectomy is the accepted method of treatment for patients with chronic thromboembolic pulmonary hypertension (CTEPH). Establishing the diagnosis and the classification of the type of lesions by pulmonary angiography is crucial for optimal patients selection. Fewer then 3,000 PEA operations have been performed worldwide, although it is potentially curative treatment option patients with CTEPH. Pulmonary endarterectomy have been performed successfully in the Czech Republic in the Clinic of Cardiovascular Surgery at the General Teaching Hospital in Prague in September 2004.

Keywords: chronic tromboembolic pulmonary hypertension; pulmonary endarterectomy

Received: December 14, 2004; Accepted: April 12, 2005; Published: November 1, 2005  Show citation

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Škvařilová M, Jansa P, Lindner J, Kunstýř J, Mayer E, Heller S, et al.. New possibilities in the treatment of chronic thromboembolic pulmonary hypertension. Vnitr Lek. 2005;51(11):1289-1296.
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