Vnitr Lek 2005, 51(1):66-70

Hypertension as a part of metabolic syndrome

H. Němcová

II. interní klinika Lékařské fakulty MU a FN u sv. Anny, Brno, přednosta doc. MUDr. Miroslav Souček, CSc.

Metabolic syndrome is a set of symptoms and diseases the integrating factor of whose is decreased tissue insulin sensitivity. Its consequences are still more important and they are prognostically serious since they relate to the diseases with mass occurence, as obesity, hypertension, diabetes, hyperlipoproteinemy. Increased insulin level as a consequence of insulinresistance leads to the weight, blood pressure and aterogenous lipids increase, significantly accelerating aterosclerosis, which is the main death cause. Therefore early detection of metabolic syndrome before the development of organ complications is necessary as well as introduction of the preventive and therapeutical measures that would decrease the cardiovascular risk as much as possible. In hypertension it means its early detection and complex effective treatment to reach both optimal blood pressure values at the concrete individual and the influence of present metabolic abnormalities. Lifestyle modification is necessary because the environmental factors significantly influence the extent to which the genetic predisposition will be exerted at last.

Keywords: metabolic syndrome; insulin resistance; hypertension; diabetes mellitus; prevention; lifestyle modification; pharmacotherapy

Received: March 15, 2004; Accepted: July 14, 2004; Published: January 1, 2005  Show citation