Vnitr Lek 2004, 50(5):408-411

[Immunopathogenesis of diabetes mellitus I].

J Krejsek, J Novosad, O Kopecký
Ustav klinické imunologie a alergologie Lékarské fakulty UK a FN, Hradec Králové.

The pathogenesis of diabetes mellitus I is multifactorial. Both genetic predisposition and environmental factors are involved in the deregulation of immune system with subsequent breakage of self-tolerance. Autoantibodies against numerous autoantigens are raised during this long-term process but the principal pathogenic mechanism is cytotoxic killing of beta cells of pancreas mediated predominantly by T cells. There could be the chance to interrupt this pathogenetic process by manipulation with immune system to achieve induction of tolerance. Such clinical trials are now under progress.

Keywords: Animals; Diabetes Mellitus, Type 1, genetics, ; Genetic Predisposition to Disease; Humans

Published: May 1, 2004  Show citation

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Krejsek J, Novosad J, Kopecký O. [Immunopathogenesis of diabetes mellitus I]. Vnitr Lek. 2004;50(5):408-411.
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