Vnitr Lek 1999, 45(2):90-96

[Effect of eradication treatment on histological changes of the gastric mucosa in patients with non-ulcer dyspesia and Helicobacter pylori infection. Randomized prospective study].

J Kyzeková

Privátní interní a gastroenterologická ambulance, Podborany.

UNLABELLED: Eradication treatment leads to improvement of gastritis. There is little information of its effect on changes in the topographic distribution and regression of actual mucosal alterations in dyspeptic patients. In a previous study we provided evidence of a complex of histopathological changes in the cardia, corpus and antrum in patients with H. pylori infection and non-ulcer dyspesia.

OBJECTIVE: To assess the effect of eradication treatment on the development of histological changes in the lower oesophagus, in the gastric cardia, corpus and antrum in patients with non-ulcer dyspesia three and six months after treatment.

METHODS: AND PATIENTS: 251 consecutive dyspeptic patients (without ulcers or gastric malignity) with H.pylori infection were investigated prospectively. Endoscopy with eight biopsies (antrum, corpus, cardia and lower oesophagus) were made before, eradication treatment and three and six months after this treatment (Pantoprazole 40 mg 1x/day, Amoxycillin 1000 2x/day, Claritromycin 500 2x/day). The biopsies were stained (H+E) and modified Giemsa to detect H. pylori. The inflammation, activity and other mucosal changess were examined semiquantitatively and evaluated according to the Sydney System.

RESULTS: In the cardia, corpus and antrum a significant decline of chronic inflammation was recorded as well as of the activity and H.pylori (p0.05) while in the corpus (p

Keywords: Adolescent; Adult; Aged; Aged, 80 and over; Dyspepsia, microbiology, ; Female; Gastric Mucosa, pathology, ; Gastritis, drug therapy, ; Helicobacter Infections, complications, ; Helicobacter pylori; Humans; Male; Middle Aged

Published: February 1, 1999  Show citation