Vnitr Lek 1999, 45(1):62-66

[A multicompartmental and multifactorial model of production of plasminogen activator inhibitor (PAI-1). II. Clinical study in patients with insulin resistance].

P Galajda, P Kubisz, M Mokán

I. interná klinika, Jesséniova lekárska fakulta, Martin.

PAI-1 levels are closely associated with insulin resistance (IR) syndrome, including patients with obesity, hypertension, hypertriglyceridaemia and type 2 diabetes mellitus (DM). Clinical studies demonstrated PAI-1 correlations with insulin (IRI), triglycerides (TG) and body mass index (BMI) values, but these relations have not been confirmed in all studies. In obesity PAI-1 levels correlate with IRI and BMI in the relation to increased adipocyte PAI-1 production, which is dependent on stimulative insulin action. In the case of endothelial hyperproduction in patients with IR elevated PAI-1 levels correlate with TG values. Insulin inhibits induced endothelial PAI-1 production. PAI-1 levels in patients with IR represent cumulative production in described tissues.

Keywords: Adipocytes, metabolism, ; Diabetes Mellitus, metabolism, ; Humans; Insulin, physiology, ; Insulin Resistance; Models, Biological; Obesity, metabolism, ; Plasminogen Activator Inhibitor 1, metabolism,

Published: January 1, 1999  Show citation