Vnitr Lek 1998, 44(2):111-114

[Plasminogen activator inhibitor (PAI-1) and diabetes mellitus. II. PAI-1 in insulin resistant conditions].

P Galajda, L Sutarík, L Vladár, J Stasko, P Kubisz, M Mokán

I. interná klinika MFN, Martin.

Insulin resistance (IR) is associated with an elevated PAI-1 level and by correlation with insulin and triacylglycerol (TG) levels. While in IR non-diabetics this relationship is close, in patients with NIDDM the mutual relationship is less marked and there are other factors which raise the PAI-1 levels such as proinsulin, oxidation stress or cytokines. Therefore achievement of satisfactory metabolic control, reduction of insulin and TG levels need not be associated with normalization of PAI-1. As it is an independent risk factor of atherosclerosis, further examinations are necessary in order to differentiate in more detail the possible causes of its rising level in order to obtain a rational basis for effective therapy.

Keywords: Diabetes Mellitus, blood, ; Humans; Insulin Resistance; Plasminogen Activator Inhibitor 1, blood,

Published: February 1, 1998  Show citation