Vnitr Lek 1998, 44(2):63-67
[Celiprolol improves glucose metabolism in essential hypertension].
- Ustav preventívnej a klinickej medicíny-klinika farmakoterapie, Bratislava.
The authors investigated in 18 patients with essential hypertension the action of celiprolol (usually in combination with a diuretic) on the glucose and lipid metabolism in an open three-month trial. They evaluated the glucose, insulin and C-peptide concentration during an oral glucose tolerance test (oGTT) and the serum lipid concentration before and after treatment. It was revealed: 1. There are no significant changes in the glucose, insulin and C-peptide concentrations on fasting, 2. There is a significant reduction of the blood sugar level during the second hour of oGTT after treatment, 3. A significant reduction of glucose and C-peptide during the 1st and 2nd hour of oGTT after treatment in the sub-group with a poor glucose tolerance/insulin sensitivity, 4. There are no differences between the mentioned variables in hypertonic patients with a normal glucose metabolism, 5. There are no significant changes in values of total cholesterol, HDL-, LDL and VLDL-cholesterol and triacylglycerols. Celiprolol can exert in combination with diuretics also a favourable effect on the glucose tolerance/insulin sensitivity in patients with essential hypertension and metabolic syndrome.
Keywords: Adrenergic beta-Antagonists, therapeutic use, ; Adult; Antihypertensive Agents, therapeutic use, ; Blood Glucose, metabolism, ; C-Peptide, blood, ; Celiprolol, therapeutic use, ; Female; Glucose Tolerance Test; Humans; Hypertension, blood, ; Insulin, blood, ; Lipids, blood, ; Male; Middle Aged
Published: February 1, 1998 Show citation