Vnitr Lek 1995, 41(2):105-109

[Insulin resistance and hyperlipoproteinemia].

J Skrha: III. interní klinika 1. LF UK, Praha.

Insulin resistance is part of the so-called plurimetabolic syndrome where it was observed in association with various signs among which the association with impaired serum lipids is very frequent. The most frequent deviations are hypertriacylglycerolaemia (in particular VLDL), low HDL-cholesterol and elevated serum levels of non-esterified fatty acids. Some hitherto assembled findings suggest a close relationship between glucose and lipid metabolism. Enhanced oxidation of non-esterified fatty acids leads to inhibition of glucose oxidation and this may participate in the development of insulin resistance. Changes in cholesterol and triacylglycerol levels seem to be rather the consequence than cause of the development of insulin resistance. It cannot be ruled out that insulin resistance is genetically conditioned and this would explain the other associated changes as secondary ones.