Vnitr Lek 1993, 39(12):1157-1163

[Primary chronic glomerulonephritis with nephrotic syndrome. Treatment with prednisone and cyclophosphamide].

V Knotková, K Němecek, I E Tarayeva, T N Krasnova

II. interní klinika 1. LF UK, Praha.

The authors present their long standing experience with immunosuppressive treatment of patients with nephrotic syndrome associated with primary chronic membranous, mesangioproliferative and mesangiocapillary glomerulonephritis. Of a total of 127 patients 99 were treated with prednisone and cyclophosphamide and 28 with cyclophosphamide only. Clinical remission developed in 89 patients (70%). Remissions developed independently on morphological findings and initial proteinuria, but more frequently in patients with a still normal glomerular filtration. In combined immunosuppression 77% of the treated patients developed remission, while only 48% treated with cyclophosphamide alone. 88% of the patients survive an average period of 10 years. From the investigation it is apparent that long-term and early combined immunosuppression has a favourable impact on the course of primary chronic glomerulonephritis with nephrotic syndrome.

Keywords: Adult; Chronic Disease; Cyclophosphamide /administration & dosage/; Drug Therapy, Combination; Glomerulonephritis, Membranoproliferative /complications/; Glomerulonephritis, Membranous /complications/; Humans; Middle Aged; Nephrotic Syndrome /complications/; Prednisone /administration & dosage/

Published: December 1, 1993  Show citation