Vnitr Lek 1993, 39(9):856-864

[Comparison of the effects of molsidomine retard and isosorbide dinitrate retard in patients with stable angina pectoris using an ergometry test].

P Rotrekl, J Vlasínová, J Manousek, B Semrád, F Rysavý, Z Lupínek, J Meluzín, I Vlasicová, I Pirochtová, O Bocek

I. klinika vnitrních chorob FNsP, Brno-Bohunice.

In 24 men with angina after exertion the authors assessed, using ergometry, the action of molsidomine retard and isosorbide dinitrate retard after a single dose and after tree-week administration of the drug. The authors found that 8 mg of molsidomine retard in a single dose had a somewhat more potent effect than 40 mg isosorbide dinitrate retard. After prolonged administration the effect of both drugs on haemodynamics diminished and in molsidomine a significant decline of action was observed before development of a reduced S-T segment on the ECG. After three weeks' administration the effects of both drugs were comparable. After neither drug clinically significant tolerance developed when the drug was administered every 8 hours. In the conclusion the authors discuss possible mechanisms involved in development of tolerance.

Keywords: Adult; Angina Pectoris, drug therapy, ; Delayed-Action Preparations; Electrocardiography, drug effects, ; Exercise Test; Heart Rate, drug effects, ; Humans; Isosorbide Dinitrate, administration & dosage, ; Male; Middle Aged; Molsidomine, administration & dosage,

Published: September 1, 1993  Show citation