Vnitr Lek 1993, 39(4):401-407
[Resistance to cytostatic agents in patients with refractory multiple myeloma and possible ways to control it].
- II. interní klinika Fakultní nemocnice, Brno.
At present several mechanisms responsible for the resistance of tumour cells to cytostatics are known. Most explored is the resistance conditioned by glycoprotein-P. Under laboratory conditions it proved possible to inhibit the resistance caused by glycoprotein-P by many substances which, however, on clinical administration have serious adverse side-effects. In practice verapamil was used, its effect was most marked in haematological malignant diseases. Side-effects of verapamil, however, do not permit to attain the necessary concentration. Obviously better results will be achieved by cyclosporin A which can attain a concentration in the organism which is necessary to inhibit glycoprotein-P without serious undesirable consequences. In the submitted paper the author reviews clinical studies concerned with possible inhibition of glycoprotein-P in patients with refractory myeloma.
Keywords: ATP Binding Cassette Transporter, Subfamily B, Member 1; Antineoplastic Agents, therapeutic use, ; Carrier Proteins, physiology, ; Cyclosporine, pharmacology, ; Drug Resistance; Humans; Membrane Glycoproteins, physiology, ; Multiple Myeloma, drug therapy, ; Verapamil, pharmacology,
Published: April 1, 1993 Show citation