Vnitr Lek 1992, 38(8):754-758

[Monitoring immunosuppression after kidney transplantation. II. Evaluation of simultaneous monitoring of CD4+ lymphocytes and the cytological reaction to standard antigenic stimulation].

J Bystron, P Jansa, K Konecný, P Vrublovský, J Zadrazil, T Grosmanová, M Petrek

Ustav imunologie lékarské fakulty UP Olomouc.

Monitoring of patients after renal transplantations by the concurrent follow up of absolute values of CD4+ lymphocytes and the cytological reaction to an antigenic stimulation in a skin abrasion reflects the actual immune state of patients and is an asset in the comprehensive diagnosis of rejection activity against the transplant in the early period (6-8 weeks) after transplantation. It can contribute also to the signalling of developing rejection activity against the graft, before the onset of the fully developed clinical picture of rejection, when it is possible by early anti-rejection therapy to prevent the functional impairment of the renal graft.

Keywords: Adult; CD4 Antigens, analysis, ; Female; Graft Rejection; Humans; Immunosuppression; Kidney Transplantation, immunology, ; Lymphocyte Activation; Male; Middle Aged; Skin Tests; T-Lymphocytes, immunology,

Published: August 1, 1992  Show citation