Vnitr Lek 1992, 38(5):417-425

[Third generation beta blockers in the treatment of hypertension].

J Widimský: Subkatedra kardiologie, Institut pro dalsí vzdĕlávání lékarů a farmaceutů, Praha.

Beta-blockers of the third generation are hybrid antihypertensive drugs which reduce the blood pressure by two mechanisms--by beta-blocking and by a dilatating action. The author presents experience assembled in Czechoslovakia with bopindolol and nebivolol which belong into the class of these substances. Treatment with beta-blockers is effective also in hypertension in elderly subjects. The author mentions a group of extensive investigations conducted abroad, comparing beta-blockers and diuretics in the treatment of hypertension. From the analysis it is apparent that beta-blockers exert a favourable effect also in primary prevention of ischaemic heart disease. In the conclusion the author deals with the strategy of treatment of hypertension associated with other diseases, using different types of beta-blockers.