Vnitr Lek 1991, 37(7-8):645-651

[Use of hemoperfusion and cholinesterase in acute poisoning with organophosphate cholinesterase inhibitors--clinical analysis of 50 patients].

M Mydlík, P Mizla, J Klimcík, K Derzsiová, S Palko

IV. interná klinika, Fakultná nemocnica s poliklinikou, Kosice.

The authors present a retrospective analysis of 50 patients with acute intoxication with various organophosphate cholinesterase inhibitors who were treated in the course of 8 years by comprehensive conservative and extracorporeal elimination treatment. The mean age of the patients was 38 years. During therapy conservative treatment was used (gastric lavage, repeated lavage of the large intestine, forced diuresis, TMB-4 fusion through activated carbon, amberlite XAD-2 and XAD-4, haemodialysis). A total of 63 haemoperfusions and 15 simultaneous haemoperfusions with haemodialysis were performed. Treatment was successful in 92%. The results of treatment depended on early attendance of the patient in the dialyzation centre, on the onset of intense comprehensive treatment and the concurrent presence of other diseases.

Keywords: Adult; Cholinesterase Inhibitors, poisoning, ; Cholinesterases, therapeutic use, ; Combined Modality Therapy; Female; Hemoperfusion; Humans; Insecticides, poisoning, ; Male; Middle Aged; Organophosphorus Compounds; Poisoning, therapy,

Published: July 1, 1991  Show citation