Vnitr Lek 1991, 37(7-8):625-632

[Isosorbide dinitrate tolerance in the treatment of patients with angina pectoris and the effect of addition of captopril on therapeutic results].

P Rotrekl, Z Lupínek, J Meluzín, M Novák

I. klinika vnitrních chorob lékarské fakulty Masarykovy univerzity, Brno-Bohunice.

The authors investigated in patients with stable angina the influence of a single dose and of long-term administration of isosorbide dinitrate alone and combined with captopril. Administration of 40 mg Iso-Mack ret. every 8 hours for four weeks did not lead to the development of tolerance. However, captopril added to isosorbide dinitrate tends to improve the investigated indicators after a single dose as well as after long-term treatment. It is probable that concurrent administration of the two drugs causes addition of their vasodilatating action and thus the vascular resistance declines, as well as the cardiac pre-load and after-load and the oxygen consumption of the heart muscle. The authors discuss possible mechanisms of the increased vasodilatation after addition of captopril.

Keywords: Adult; Angina Pectoris, drug therapy, ; Captopril, administration & dosage, ; Drug Therapy, Combination; Drug Tolerance; Humans; Isosorbide Dinitrate, administration & dosage, ; Male; Middle Aged

Published: July 1, 1991  Show citation