Vnitr Lek 1991, 37(6):541-547

[The effect of alcohol on the mitochondrial respiratory chain in the cardiac muscle].

A Gvozdjáková, J Kucharská, E Miklovicová, P Bozek, J Gvozdják
Farmakobiochemické laboratórium LF UK, Bratislava.

The authors investigated the action of prolonged 2- and 3-week action of ethanol on the main parameters of oxidative processes and on the cytochrome content of mitochondria in the heart muscle in 3-month-old rats. They found a statistically significant reduction of the oxidative phosphorylation coefficient, the rate of energy formation and a transient increase of the cytochrome oxidase activity in mitochondria. Under these experimental conditions an increase of cytochromes (cyt aa3, b, c, c1, bc1, c + c1) in mitochondria of the heart muscle occurred.

Keywords: Animals; Cytochromes, metabolism, ; Electron Transport Complex IV, metabolism, ; Ethanol, pharmacology, ; In Vitro Techniques; Male; Mitochondria, Heart, drug effects, ; Oxidative Phosphorylation, drug effects, ; Rats; Rats, Inbred Strains

Published: June 1, 1991  Show citation

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Gvozdjáková A, Kucharská J, Miklovicová E, Bozek P, Gvozdják J. [The effect of alcohol on the mitochondrial respiratory chain in the cardiac muscle]. Vnitr Lek. 1991;37(6):541-547.
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