Vnitr Lek 1991, 37(1):13-20

[Disorders of fibrinolysis and thrombophilic states, risk factors and possibilities of dietary effects].

V Cepelák, J Dvorák, L Vít, H Cepeláková, V Beránek

I. interní klinika LF UK Plzen.

An inadequate efficiency of the fibrinolytic system was revealed in 50-60% of subjects suffering young age from venous thrombosis or myocardial infarction. In a group of 27 patients with the history of deep venous thrombosis of the idiopathic type the authors revealed a significant relationship between the elevated body weight and inadequate fibrinolysis manifested by a reduced fibrinolytic capacity and excess inhibitor of plasminogen activator and its inadequate decline after desmopressin infusion (DDAVP). In a group of 29 patients, who had suffered a myocardial infarction when young, the authors revealed a significant association between reduced fibrinolytic capacity and elevated body weight, hypertriglyceridaemia and increased immunoreactive insulin secretion after a glucose load. In half the investigated subjects it proved possible to improve the reduced fibrinolytic capacity by a low energy diet.

Keywords: Adult; Deamino Arginine Vasopressin, pharmacology, ; Energy Intake; Female; Fibrinolysis, drug effects, ; Humans; Male; Middle Aged; Myocardial Infarction, blood, ; Risk Factors; Thrombophlebitis, blood,

Published: January 1, 1991  Show citation