Vnitr Lek 1990, 36(3):266-269

[Severe antihistamine poisoning complicated by ventricular tachycardia].

J Bastecký, J Kvasnicka, J Vortel, M Tauchman, V Wasylivová
I. interní klinika, Fakultní nemocnice--KUNZ, Hradec Králové.

A 26-year-old female clerk without previous heart disease ingested with suicidal intensions antihistaminic drugs--H1 blockers, astemizole (a total of 700 mg) and terfenadine (a total of 900-1200 mg). The main sign of intoxication was repeated polymorphous ventricular tachycardia type torsade de pointes, which at the onset of hospitalization changed into ventricular fibrillation. Therapeutically the impaired rhythm was controlled by electric cardioversion and atrial stimulation with a frequency of 120/min. On the third day it was possible to discontinue atrial stimulation and later the patient was discharged without any permanent sequelae.

Keywords: Adult; Astemizole; Benzhydryl Compounds, poisoning, ; Benzimidazoles, poisoning, ; Female; Histamine H1 Antagonists, poisoning, ; Humans; Tachycardia, chemically induced, ; Terfenadine; Ventricular Fibrillation, chemically induced,

Published: March 1, 1990  Show citation

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Bastecký J, Kvasnicka J, Vortel J, Tauchman M, Wasylivová V. [Severe antihistamine poisoning complicated by ventricular tachycardia]. Vnitr Lek. 1990;36(3):266-269.
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