Vnitr Lek 1989, 35(11):1125-1131

[Is absorption hemoperfusion effective in the treatment of baclofen poisoning?].

V Monhart, M Balíková

By six-hour sorption haemoperfusion over active charcoal in a 33-year-old woman intoxicated with baclofen (Baclofen Polfa) the initial plasma concentration was reduced by 87%, while from the blood only 3% of the ingested dose were removed. Therefore the capacity of baclofen elimination was tested by perfusion and dialysis in vitro. Two-hour dialysis with the Czechoslovak haemodialyzer Chiraplat was equally effective for removal of baclofen from an aqueous solution (21.2 mg) as four-hour perfusion over active charcoal and resin--Czechoslovak haemoperfusion columns Hemasorb 800 C (19.4 mg) and Hemasorb 800 A-4 (18.9 mg). Because during the first 30 minutes of perfusion the resin sorbent has a double extraction, as compared with dialysis, it is better to use in serious intoxication haemodialysis and haemoperfusion concurrently.