Vnitr Lek 2016, 62(5):406-412

Can fish oil improve wound healing in surgery?

Jana Neuwirthová*, Břetislav Gál, Pavla Urbánková, Pavel Smilek
Klinika otorinolaryngologie a chirurgie hlavy a krku LF MU a FN u sv. Anny v Brně

A surgical insult induces both local and systemic inflammatory responses which, if inappropriate, could impair wound healing. According to many studies ω-3 polyunsaturated fatty acids from fish oil improve the process of wound healing by their immunomodulatory effect. In contrast to current anti-inflammatory drugs, which could alter immune defence and impair the resolution of inflammation, ω-3 fatty acids have a simultaneous anti-inflammatory pro-resolution effect which is not immunosuppressive. Besides that they improve cicatrix quality. With regard to this effect they prevent excessive or prolonged inflammation and wound complications.

Keywords: anti-inflammatory agent; cicatrix; fish oil; macrophage; ω-3 fatty acid; resolution of inflammation; Toll-like receptor; wound healing

Received: December 19, 2015; Accepted: March 4, 2016; Published: May 1, 2016  Show citation

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Neuwirthová J, Gál B, Urbánková P, Smilek P. Can fish oil improve wound healing in surgery? Vnitr Lek. 2016;62(5):406-412.
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