Vnitr Lek 2010, 56(10):1050-1052

Complications of obesity - pathogenesis

B. Krahulec
II. interná klinika Lekárskej fakulty UK a UN Bratislava, Slovenská republika, prednosta prof. MUDr. Andrej Dukát, CSc., FESC

Author discuss possible patogenetic mechanisms of obesity complications. He separates metabolic complications, especially risk factors of atherosclerosis collected in syndrome of insulin resistance. Here can be added also hyperuricaemia and nonalcoholic fatty liver disease. Mechanical complications of obesity are first of all breath disorders, gastrooesophageal reflux disease and ostaoarthritis.

Keywords: complications of obesity; pathogenesis; metabolic complication; mechanical complication

Received: July 7, 2010; Published: October 1, 2010  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Krahulec B. Complications of obesity - pathogenesis. Vnitr Lek. 2010;56(10):1050-1052.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Müllerová D et al. Obezita - prevence a léčba. Praha: Mladá fronta 2009.
    2. Rasouli N, Kern PA. Adipocytokines and the metabolic complications of obesity. J Clin Endocrinol Metab 2008; 93 (11 Suppl 1): S64-S73. Go to original source... Go to PubMed...
    3. Malnick SD, Knobler H. The medical complications of obesity. QJM 2006; 99: 565-579. Go to original source... Go to PubMed...
    4. Ukropcová B, Ukropec J, Klimeš I at al. Endokriná funkcia tukového tkaniva. Via Practica 2008; 5: 115-121.
    5. Galajda P. Metabolický syndróm, kardiovaskulárne a metabolické riziká. Via Practica 2007; 4: 5-9.
    6. Krahulec B. Inzulínová rezistencia a kardiovaskulárne následky - významná úloha endotelovej dysfunkcie. Diabetes Obezita 2003; 3: 9-15.
    7. Wilson PW, D'Agostino RB, Sullivan L et al. Overweight and obesity as determinants of cardiovascular risk: the Framingham experience. Arch Intern Med 2002; 162: 1867-1872. Go to original source... Go to PubMed...
    8. Haffner SM, Lehto S, Rönnemaa T. Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med 1998; 339: 229-234. Go to original source... Go to PubMed...
    9. Anděl M, Polák J, Kraml P et al. Chronický mírný zánět spojuje obezitu, metabolický syndrom, aterosklerózu a diabetes. Vnitř Lék 2009; 55: 659-665. Go to PubMed...
    10. Song YM, Sung J, Davey Smith G et al. Body mass index and ischemic and hemorrhagic stroke: a prospective study in Korean men. Stroke 2004; 35: 831-836. Go to original source... Go to PubMed...
    11. Curtis JP, Selter JG, Wang Y et al. The obesity paradox: body mass index and outcomes in patients with heart failure. Arch Intern Med 2005; 165: 55-61. Go to original source... Go to PubMed...
    12. Benjamin EJ, Levy D, Vaziri SM et al. Independent risk factors for atrial fibrillation in a population-based cohort: the Framingham Heart Study. JAMA 1994; 271: 840-844. Go to original source... Go to PubMed...
    13. Brůha R, Dvořák K. Nealkoholická steatóza a steatohepatitída. Interní Med 2007; 5: 210-212.
    14. Suzuki A, Lindor K, St Saver J et al. Effect of changes on body weight and lifestyle in nonalcoholic fatty liver disease. J Hepatol 2005; 43: 1060-1066. Go to original source... Go to PubMed...
    15. Ishizaka N, Ishizaka Y, Toda E et al. Association between serum uric acid, metabolic syndrome, and carotid atherosclerosis in Japanese individuals. Arterioscler Thromb Vasc Biol 2005; 25: 1038-1044. Go to original source... Go to PubMed...
    16. Tsunoda S, Kamide K, Minami J et al. Decreases in serum uric acid by amelioration of insulin resistance in overweight hypertensive patients: effect of a low-energy diet and an insulin-sensitizing agent. Am J Hypertens 2002; 15: 697-701. Go to original source... Go to PubMed...
    17. Bickelmann AG, Burwell CS, Robin ED et al. Extreme obesity associated with alveolar hypoventilation: a Pickwickian syndrome. Am J Med 1956; 21: 811-818. Go to original source... Go to PubMed...
    18. Teichtahl H. The obesity-hypoventilation syndrome revisited. Chest 2001; 120: 336-339. Go to original source... Go to PubMed...
    19. Matějovič M. Obézní pacient v intenzivní péči. In: Müllerová D et al (eds). Obezita - prevence a léčba. Praha: Mladá fronta, 2009: 246-250.
    20. Hampel H, Abraham NS, El-Serag HB. Meta-analysis: obesity and the risk for gastroesophageal reflux disease and its complications. Ann Intern Med 2005; 143: 199-211. Go to original source... Go to PubMed...
    21. Pottie P, Presie N, Terlain B et al. Obesity and osteoarthritis: more complex than predicted! Ann Rheum Dis 2006; 65: 1403-1405. Go to original source... Go to PubMed...

    Return to the content


    Vnitřní lékařství

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.