Vnitr Lek 2008, 54(9):821-826

Inflammatory reaction and its importance in the course of tumour process

D. Hlávková^1,*, O. Kopecký^2,3, Š. Lukešová^2,3

¹ Ústav klinické imunologie a alergologie Lékařské fakulty UK a FN Hradec Králové, přednosta prof. RNDr. Jan Krejsek, CSc.

² Oddělení klinické imunologie a alergologie Oblastní nemocnice Náchod, a.s., přednosta doc. MUDr. Otakar Kopecký, CSc.

³ II. interní klinika Lékařské fakulty UK a FN Hradec Králové, přednosta prof. MUDr. Jaroslav Malý, CSc.

This article gives basic information about the formation and the course of the inflammatory reaction, which is the important adaptation mechanism of the organism on the various external and internal injurants. The main attention is fixated on the role of the immune system in the course of the inflammatory reaction. It deals with the presence and the sense of the inflammatory reaction in the tumour environment in more detail. It gives the short information about the mechanisms of the antitumour defence. The influence of the inflammatory reaction on the genesis, the course and the progression of the tumour disease is discussed in the third chapter.

Keywords: inflammatory reaction; immune system; antitumour imunity; tumour microenvironment; cytokines; chemokines

Received: December 14, 2007; Accepted: April 11, 2008; Published: September 1, 2008  Show citation