Vnitr Lek 2002, 48(5):403-408

[Specific inhibitors of cyclooxygenase type 2] ].

J Tomasová-Studýnková: 3. lékarská fakulta UK, Revmatologický ústav, Praha.

Klíčová slova: Anti-Inflammatory Agents, Non-Steroidal, adverse effects, ; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors, adverse effects, ; Humans; Isoenzymes, antagonists & inhibitors, ; Lactones, adverse effects, ; Membrane Proteins; Prostaglandin-Endoperoxide Synthases, physiology, ; Pyrazoles; Sulfonamides, adverse effects, ; Sulfones

In the submitted review the author analyzes the ratio, function and role of two different forms of cyclooxygenases--cyclooxygenase type 1 and cyclooxygenase type 2--in the human organism. Special attention is devoted to specific inhibitors of cyclooxygenase type 2. Specific inhibition of COX-2 is associated with a lower incidence of undesirable reactions while the antiinflammatory and analgetic effect is preserved. Celecoxib and rofecoxib--the oldest representatives of drugs from this group were used in a number of clinical studies. The results of some of these studies are presented and commented.