Vnitr Lek 1995, 41(2):76-83

[Cellular and molecular mechanisms of insulin resistance].

E Seböková, I Klimes, P Stolba: Skupina pre stúdium diabetu a porúch výzivy, Ustav experimentálnej endokrinológie, Slovenská akadémia vied, Bratislava.

Klíčová slova: Humans; Insulin, physiology, ; Insulin Resistance, physiology, ; Molecular Biology; Syndrome

In the submitted review the authors give an account of contemporary knowledge regarding the mechanism of insulin action, including a brief account of pathological conditions associated with insulin resistance. The development of knowledge of problems of insulin resistance syndromes was always very dynamic, and due to the introduction of techniques of molecular biology and genetics at the turn of the eighties and nineties, a further very marked step forward was made. Despite this it will take some time before molecular mechanisms which will confirm (or rule out?) the etiopathogenetic importance of insulin resistance not only for diabetes but also for hypertension, dyslipidaemia, IHD will be revealed.