Vnitr Lek 1991, 37(6):541-547
[The effect of alcohol on the mitochondrial respiratory chain in the cardiac muscle].
- Farmakobiochemické laboratórium LF UK, Bratislava.
Klíčová slova: Animals; Cytochromes, metabolism, ; Electron Transport Complex IV, metabolism, ; Ethanol, pharmacology, ; In Vitro Techniques; Male; Mitochondria, Heart, drug effects, ; Oxidative Phosphorylation, drug effects, ; Rats; Rats, Inbred Strains
The authors investigated the action of prolonged 2- and 3-week action of ethanol on the main parameters of oxidative processes and on the cytochrome content of mitochondria in the heart muscle in 3-month-old rats. They found a statistically significant reduction of the oxidative phosphorylation coefficient, the rate of energy formation and a transient increase of the cytochrome oxidase activity in mitochondria. Under these experimental conditions an increase of cytochromes (cyt aa3, b, c, c1, bc1, c + c1) in mitochondria of the heart muscle occurred.
Keywords: Animals; Cytochromes /metabolism/; Electron Transport Complex IV /metabolism/; Ethanol /pharmacology/; In Vitro Techniques; Male; Mitochondria, Heart /drug effects/; Oxidative Phosphorylation /drug effects/; Rats; Rats, Inbred Strains
Zveřejněno: 1. červen 1991 Zobrazit citaci