In 52 subjects where after 10.6 +/- 7 years after detection of glycosuria on fasting normal glucose tolerance persists some risk factors and early biochemical changes indicating possible later development of diabetes were evaluated. 73% of the subjects had a positive family-history of diabetes and 61% were obese. In 42% of the subjects during the present examination glucose in urine was detected only after a glucose load. In 35% of the subjects pathological serum values of glycoproteins were found and their mean fasting blood sugar levels and levels 60 minutes after a glucose load were significantly higher, although in the range of normal oGTT, as compared with the group with normal glycoprotein levels. 21% had pathological values of N-acetyl-beta-D-glucosaminidase levels in serum and urine and concurrently significantly higher IRI values 60 and 120 minutes after a glucose load, than the group with a normal value. In obese subjects, as compared with those with a normal body weight, there were significantly higher mean blood sugar levels on fasting and 60 minutes after a glucose load and the same applies to IRI levels on fasting and after 60 minutes following stimulation. The authors discuss the causes and interrelations of the assembled results.

Keywords: Adult; Diabetes Mellitus /diagnosis/; Female; Glucose Tolerance Test; Glycosuria; Humans; Male; Middle Aged; Obesity /metabolism/