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PŘEHLEDOVÉ42522001004388130181216258306358404446
ČLÁNKY88722001003973122176223272
Moderní425330010061100139174198237252
léčba6933300100155081120155
hereditárního8643300100377297132170186212249273311327366405
angioedému128533001003471110125164199238274334371
s1672330010029
deficitem17173300100377291109139154181216276
C1200933001003964
inhibitoru:20893300100145290105143158185224248287302
od240733001003876
kontroly250033001003371109135160199215251
atak27673300100346197131
k2914330010034
úplné29643300100377590128163
kontrole314333001003472110136161200216251
onemocnění341033001003876111171210241279315353368
40017822001004087132
|350220010018
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dostupné126262001075098131160208257306350
v1637620010741
režimu170362001072770107125199246
individuální197562001071966116134175194243290331349397415
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1648776001074482
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č.85176001074056
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Sb.,122176001074290104119
o1356760010748
veřejném142176001074083108150168215258331
zdravotním176876001073784110150189236262310327400
pojištění.218476001075098117134166194235282300315
U2515760010757
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pacientů42590001075090130148191238264311
je75190001072063
ikatibant8299000107195697124142190231278304
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úhrady243390001074795120161209249
podle269790001075098147165208
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uvedeného591104001074888130180223270313361408
zákona.1021104001073677115161209248264
V13061040010746
době1374104001074996145189
přípravy158510400107507594142168209248290
tohoto1897104001072873121169195241
článku215910400107415898145182230
jsou241010400107195199146
garadacimab25781040010749881141552032432833004251180010773113161
a6001180010741
donidalorsen655118001074996143161208248265312338371414460
dostupné1130118001074995128155202250297340
na1485118001074887
základě1586118001073677114133172221263
individuální1864118001071865113130170188236282321339385403
úhrady2281118001074894119160208247
podle2542118001074997146164206
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162824118001074481
zákona425132001073678115161209249
č.692132001074055
48/1997765132001074488119160197241281
Sb.,1064132001074290104119
o12011320010748
veřejném1267132001074083108150168215258331
zdravotním1616132001073683109149188235261309326399
pojištění.2033132001075098116134165193235282299314
Centralizace565146001075192138164189229247264299339378419
péče998146001074993132173
do1185146001074995
omezeného12941460010748120163198240286329375422
počtu1730146001075097137165212
center1956146001073980127152193218
umožňuje21881460010748119166200247293310353
zachování2555146001073676115162208247287333351
vysoké425160001074081113160197238
odbornosti676160001074896143190216262309340368385
a10751600010740
zkušeností1129160001073672118149191238284316343360
s15031600010733
diagnostikou1550160001074865104151197243275302319355401447
a20111600010740
léčbou2065160001071860100147194240
tohoto2319160001072772119165191235
vzácného2568160001074077118156202245291337
onemocnění425174001074896139212259300347390437455
a8981740010740
současně956174001073481129168209241288331
zajišťuje130517400107367896113145174220238281
pacientům1604174001075090130148191238264311383
přístup200517400107507694126154201249
k22721740010738
moderní23281740010774122171214240288305
terapii.265117400107286995136184203220235
Závěr3047590013862122182238284
Léčba318776001074083125174215
HAE-C1-INH3423760010757109151177232272295316373430
prošla387376001075077124157176217
v4110760010741
posledních417276001074998132151195245293311351399
letech45927600107196391133175223
zásadním483576001073779112154203251270343
vývojem.519976001074184128176195239312329
Moderní3047900010770119170214241290308
cílená33829000107405980124172213
léčba362290001071963105154196
umožňuje3845900010748122170206255303322366
u4237900010748
většiny431290001074184112147165213252
pacientů459090001075092133152196244271319
významně493690001074184123173213287336380
snížit534390001073381100137156184
frekvenci304710400107245398137183228278320339
atak3414104001074270113153
a35951040010741
v36641040010742
řadě3734104001072770121167
případů392910400107517999150193244293
dosáhnout42501040010750100135179229278329379408
jejich468610400107206585104146196
úplné49101040010749100121170216
eliminace.515410400107456584160180229272314358373
Současný3047118001074291139180221255303342
trend341511800107285598147196
směřuje36381180010734107152177226245289
k39541180010738
jednodušším4018118001072064114163211262309342376394468
formám451311800107237198173214288
podání,48271180010750100150191239258274
individualizované51271180010719671171361771972462943353543723047132001073684124166214259
terapii333213200107287198139189209227
a35861320010741
v36531320010741
budoucnu3720132001075099149197246286335383
potenciálně4129132001075099127170218259277318337385429
i45851320010719
ke4630132001073882
kurativním4738132001073887113155183202243292311385
přístupům514913200107507796129158207256305378
založeným304714600107367997146181224272311385
na3452146001074889
genové3560146001074993141189230273
terapii.385214600107287097138188207226242
Cílem411314600107516990134208
léčby4340146001071963104153193
již455214600107193874
není4645146001074993141159
pouze4824146001074998147184226
zvládání5070146001073680100140190230278297
jednotlivých53861460010719631133047160001074897124143161202246285333
atak,3401160001074068109147165
ale3586160001074160104
dosažení3710160001074997131173210253301319
plné4049160001075070117162
kontroly4231160001073885134161187234254294
onemocnění4545160001074897141215263304353397445463
a50281600010741
normalizace5089160001074997124198239258276313355396438
kvality3047174001073882123142161189231
života329817400107365597144171213
pacientů.3530174001075092132151195243270317332
PROHLÁŠENÍ48520400974387144199239292335376430452
AUTORŮ:954204009749101143200245299316
Prohlášení128620300984573119166187229263305352373
o1674203009845
původnosti:173520300984693134179227274320354383404423
Publikace217420400954082127144161195233269308
byla24982040095447997133
zpracována264720400953378102139176218254291334371
s3034204009529
využitím307920400953775119152169195212277
uvedené337220400954380119163203246286
literatury3674204009517335997121158183226249288
a3978204009536
nebyla403020400954383127163181217
publikována426320400954487132150166200243279316359396
ani46752040095367996
zaslána478720400953270100117153197233
k5036204009534
recenznímu50862040095236299137180213257274340382
řízení4852160095244174112156172
do67521600954387
jiného7792160095173477117160203
média.1000216009565105150167203218
Střet12352150098426998141170
zájmů:142121500983679100169215234
Žádný.167321600954380125168202213
Financování:190421500984161108149195232277318359406427446
Ne.236721600955191104
Registrace248821500984688135156190219248290326368
v2872215009841
databázích:293021500984687116158205247284306342389408
N/A.335521600955180122139
Projednání351221500984573119141183231278319365387
etickou39152150098417192128170214261
komisí:419221500984186155176210231250
N/A.445921600955180122139
LITERATURA426239001234978134189250318368438498567
1.42525600853648
Reshef4862560083357096134168187
A,68625600834054
Buttgereit7532560083357395119156191212245260282
T,104825600833241
Betschel11022560083357092119151188223238
SD,13532560083327788
et145325600833456
al.15222560083314659
Definition,15942560083458097114151166188203241279291
acronyms,18982560083326384121159189248274286
nomenclature,219725600833775133168205237252284306343364398409
and261925600833269108
classification27392560083324778105131145425266008317346698120135173212
of64926600833857
angioedema71926600833169108123161196236271328361
(DANCE):109226600831965104149190223242254
AAAAI,135926600834184127170185198
ACAAI,156926600834180123166181194
ACARE,177526600834180123159192205
and199326600833270108
APAAACI211426600834177114157200239254
DANCE238126600834584129170203
consensus.259726600833168106132167205231268294308
J425276008324
Allergy4642760083415772107128166198
Clin6782760083405570108
Immunol.80127600831572130168206244260273
2024;154(2):398-411.e1.108927600833569101133145175205241260294312324359392427450486517544554589618628
2.42528600853651
Vázquez4892860083356696134171206235
DO,73728600834593104
Giavina-Bianchi8542860083435991122137175207229266281313351383421436
P,130228600833540
Josviack13552860083246288121137169201230
D,159828600834556
et166728600833456
al.17362860083314659
The180828600833372106
2025192728600833468101135
WAO207528600835796142
Guidelines22302860083438196135169185200237272299
for25412860083195677
the26312860083226095
classification,27382860083314779105131146425296008317346699121136174212225
diagnosis,6652960083395486125163201228243269282
and96229600833270109
treatment10872960083214377109130188223262283
of138629600833756
hereditary14582960083377293127167182205237258292
angioedema,176629600833270109124162197237272330362375
with21572960083506688126
consideration229929600833168106133148186221243276297313351389
of270329600833857
worldwide27762960083508810942530600831554105121159194
disparities.6353060083385379118151172188210225260287301
World95130600835794115131170
Allergy11363060083415772107128166198
Organ135030600834768106139177
J.154230600832437
2026;19(5):101335.159430600833468101135147177207227260278290320352383413446479491
3.42531600853651
Bork4893160083357495126
K,62831600833550
Wulff69131600835794109129148
K,85231600833550
Witzke9153160083577396127157191
G,111931600834458
et119031600833456
al.12593160083324760
Hereditary133231600834580101135174190212245266300
angioedema164531600833270109124162198237272330362
with20203160083516789127
normal21603160083387698156189204
C1-INH23773160083407291107153197
with25873160083516789127
versus27273160083326687115152178
without4253260083516689127165203226
specific66632600832665101133148166183215
F128963260083336494
gene100632600833873111146
mutations.116732600835795118150172187225264290304
Allergy.14863260083415772106128166198208
2015;70(8):1004-1012.170932600833468100130141174207227260278290320351388424447478509541571583
4.42533600853651
Bork4933360083357495126
K,63633600833549
Machnig70233600835587119157195210249
T,96833600833342
Wulff102633600835895110130149
K,119133600833550
et125833600833456
al.13313360083324760
Clinical14083360083405570108123155188203
features16283360083185385106144166200226
of187133600833857
genetically194533600833873111146168183215248264279310
characterized227233600833169102123156188212246267283312346386
types26743360083225696131158
of284933600833757
hereditary4253460083387394128167183205238259293
angioedema73534600833270109124162198237272330362
with11143460083516689127
normal12583460083387698156188204
C1147934600834072
inhibitor:15683460083145290105145160183219241255
a1840346008332
systematic18893460083265885109142200233254270302
review22083460083205487102137188
of241334600833757
qualitative248734600833876108123138161193215230263297
evidence.2801346008334678242535600833873111143177189
Orphanet62935600834769109147180218253275
J919356008325
Rare9593560083356889123
Dis.10983560083456087100
2020;15(1):289.121335600833569102136148179209226258272284319353387398
5.42536600853650
Baroš4923660083356889127153
J,66136600832436
Hakl71336600834577107124
R,85336600833549
Pešák9183660083356995128158
S,109236600833346
et115436600833456
al.12263660083324760
Angioedém130236600834179118133171207246281339
jako16573660083154777115
nežádoucí178836600833772101135174212250282297
účinek21013660083387085122157188
léčby23053660083154982121152
různými24733660083215988127157216231
farmaky.272036600831852731311644253760083306474
Vnitřní5143760083357388110132170185
lékařství.7143760083155080114135162185220235248
2025;71(8):517-523.97837600833468101136146179212227260278290326357386405439472507519
6.42538600853652
Riedl4963860083355186125140
MA,65538600835597111
Bernstein7853860083357091130156180213229266
JA,10703860083246479
Li116738600833247
H,123338600834457
et130938600833456
al.13843860083324760
Recombinant146338600833570103140198238253291323361383
human186538600833775133165203
C1-esterase20873860083407291127154177211232265291326
inhibitor24323860083155391106145161183220242
relieves2693386008320547085120152186213
symptoms42539600832659117156179215274300
of74139600833857
hereditary8143960083387394128168183205238259293
angioedema112339600833270109124162198237272330363
attacks:15023960083325378111143173202214
phase173339600833877109136171
3,192039600833446
randomized,19823960083215492131169227243272306345358
placebo-controlled23563960083395587119153192231254288325363385406444459475509549
trial.425406008322435991106119
Ann55940600834179117
Allergy6924060083415671106127165198
Asthma9054060083416992130188220
Immunol.114140600831472130168206244260273
2014;112(2):163-169.e1.142940600833468100131143173201231248282300312341373406428459490524535570600609
7.42541600853645
Bork4834160083357495126
K.62241600833550
Pasteurized6854160083356794117151188209225254288328
and102641600833270109
nanofiltered,114841600833769108146164181196218252273307347359
plasma-derived15204160083395587114171204226266301323338371405445
C1197841600833972
esterase20634160083346084117139171198233
inhibitor23094160083155391106145160183220241
concentrate256341600833268107139173211232254287309342
for4254260083185678
the5184260083226095
treatment6284260083224377109131189224262284
of92742600833756
hereditary9994260083377294128167182205238259293
angioedema.130742600833270109124162198237272330362376
Immunotherapy.169842600831572130168206244266304339360393433464474
2014;6(5):533-551.218742600833468100131143179198231250262297330363385419451482492
8.42543600853652
Moldovan49043600835493109148186218251289
D,79243600834556
Bernstein8614360083357092130157180213229266
JA,11404360083256579
Cicardi12324360083405587120141179194
M.143943600835568
Recombinant152143600833570103139198237252290323361382
replacement19164360083215594110142174208266301339361
therapy22904360083215994116149188219
for25224360083185678
hereditary26134360083377293127167182204237258292
angioedema42544600833270109124162197237272330362
due80244600833976111
to92844600832259
C1100244600834072
inhibitor10904460083145290105144160182219241
deficiency.13464460083387391108140155189228260293303
Immunotherapy.166544600831472130168206244266304339360393432464474
2015;7(7):739-752.215444600833468100130141174190225244256289324357380412444478490
9.42545600853649
Cicardi4904560083405587120141179194
M,70045600835468
Banerji78345600833568106141162178193
A,99245600834055
Bracho10624560083355790122160198
F,127545600833339
et132945600833456
al.14004560083324760
Icatibant,14764560083144779101116156189227248261
a1753456008331
new180045600833772123
bradykinin-receptor19394560083386093132164195211249264302324346380413447486508545567
antagonist,25214560083327091124163201240255281304317
in285345600831553
hereditary4254660083387394128167183205238259293
angioedema.73346600833270109124162198237272330362376
N1124466008345
Engl118446600833371110125
J1324466008324
Med.136446600835489129142
2010;363(6):532-541.152146600833468100132145180214248266299317329364397430450484519550559
10.4254760085367085
Cicardi5284760083405587120141179194
M,74147600835467
Levy8274760083316597131
RJ,9774760083356274
McNeil106947600835487132167182197
DL,12844760083467891
et139347600833457
al.14684760083324760
Ecallantide15464760083336497112127159198219234273308
for18724760083195678
the19684760083216095
treatment20814760083214377109130189224262283
of238247600833857
acute245747600833264102124158
attacks26334760083325478111143173202
in285347600831553
hereditary4254860083387394128167183205238259293
angioedema.73348600833270109124162198237272330362376
N1124486008345
Engl118448600833371110125
J1324486008324
Med.136448600835489129142
2010;363(6):523-531.152148600833468100132145180214248266299317329364398432454488521552561
11.4254960085356577
Riedl5144960083355084123138
MA,66449600835495109
Farkas7854960083326182112144170
H,96849600834356
Aygören-Pürsün103649600834170107145166199237259295331352379415453
E,150149600833245
et155849600833455
al.16264960083314659
Oral169749600834668100115
Sebetralstat182449600833267105140162183215230256278310332
for21684960083185576
On-Demand225649600834785107153188245276314352
Treatment26204960083324983114135192227264285
of42550600833757
Hereditary49750600834479100134174189211244265299
Angioedema81250600834179118133171207246281339371
Attacks.11995060083416286119151181210224
N1438506008345
Engl149850600833370109125
J1638506008324
Med.167750600835590130143
2024;391(1):32-43.183550600833468101133145180213245260292306318353386406443475488
12.4255160085366884
Maurer52251600835487125146180201
M,73651600835568
Stobiecki8185160083325390130145180213243259
M,109051600835568
Valerieva11725160083356682117138154188221253
A,143951600834155
et150751600833456
al.15775160083324760
Oral165051600834769102117
deucrictibant178151600833873110143164179211235251290323361382
for21775160083185677
on-demand22685160083377598138173231263301340
treatment26225160083214377109131189224262283
of42552600833756
hereditary4945260083387394128167182205237259293
angioedema79952600833270109124162197237272329362
attacks11745260083315377110142172201
(RAPIDe-1):13885260083185497133147193228251282296308
a1709526008332
randomised,17545260083205391130168226241267302342354
double-blind,212152600833876114153169204227267283298335374387
placebo-controlled,25215260083395486119152191230253287324362425536008322438096111146186198
phase63953600833877109136171
2825536008334
trial.875536008321435890106119
Lancet100953600833165103135169191
Haematol.121553600834477112169202224260276289
2026;13(4):e200-e214.152053600833468101134147177207225258275287321356390426450486521552583596
13.4255460085366883
Zanichelli52554600833871109124156194229244259274
A,81654600834155
Ghezzi88854600834482117147178194
M,109854600835568
Santicchia118354600833365103125140172203241256288
I,148854600831527
et153254600833456
al.16055460083324760
Short-term168254600833270109130155174197231252310
prophylaxis20095460083396097137176206222254286301328
in235354600831553
patients24235460083387193108143181203230
with26705460083516689127
angioedema2813546008332704255560083385391127166201259291
due73155600833876111
to85655600832259
C1-inhibitor9305560083407291107144182198237252275312333
deficiency12785560083387390107139155189227259293
undergoing158655600833775114149170208246262300339
dental193955600833873111133166181
procedures:21355560083396097130164203241262296323335
An248555600834179
observational2579556008337771041391601952272492653034255660083387085
study.5265660083264987126158168
PLoS70956600833566104136
One.86056600834786121133
2020;15(3):e0230128.100856600833468101135148178208226260277289323359392426461493523556570
14.4255760085366883
Longhurst52157600833168106145182219240267290
HJ,8235760083446981
Cancian91657600834072110142157188226
M,115457600835468
Grivcheva-Panovska12345760083446580112143181215247280302338370407445477503533566
V,181357600833544
et186957600833456
al.19385760083314659
Hereditary200957600834479100133172187209242263296
Angioedema231857600834178117132169204243278335367
Attacks26985760083406185118149179208
in42558600831553
Patients4975860083356789104139177198226
Receiving74358600833570103136152184200238277
Long-Term103958600833269108147169199230251309
Prophylaxis:13685860083355693132171202218250281297323335
A1723586008341
Systematic17845860083326289112146204236258273305
Review.210958600833570102118153204215
Clin23435860083405570108
Rev247158600833570102
Allergy25935860083415671106127166198
Immunol.28105860083157342559600835795133171187200
2024;67(1-3):83-95.64059600833569102133145181214230262281313330342377411433468502514
15.4256060085366883
Banerji52460600833568106141163178193
A,73360600834155
Busse80460600833673100126161
P,98160600833540
Shennak103760600833270105143181213243
M,129660600835568
et138060600833456
al.14526060083324760
Inhibiting15286060083155391106145160183198236275
Plasma18196060083355082108166198
Kallikrein2033606008335698499114144167201216254
for23036060083185677
Hereditary239660600834479100134174189212244265300
Angioedema27116060083417911813417242561600833473108166199
Prophylaxis.6396160083355693133171202218250282297323337
N991616008345
Engl105161600833370109125
J1191616008324
Med.123161600835489129142
2017;376(8):717-728.138861600833468100130139174206238257291309321354387416435466500534547
16.30472560085366985
Riedl31502560083355186125140
MA,330825600835496110
Bernstein34362560083357092130157180214229267
JA,37202560083246478
Craig38162560083406194109148
T,398125600833342
et404025600833456
al.41142560083324760
An419125600834180
open-label428825600833777112151173189222261296312
study46172560083275088127159
to479325600832259
evaluate48692560083346699115152185206240
the51272560083215994
long-term52392560083155391130153175209230288
safety30472660083265978113135169
and323326600833169108
efficacy3358266008334537088120153185219
of359426600833756
lanadelumab36672660083154785118157192207245302335374
for40582660083185677
prevention41522660083396195127161199221236274313
of448126600833857
attacks45552660083325378110143173202
in477326600831553
hereditary48432660083377294128167182205238259293
angioedema:515326600833170109124162197237272330362374
design304727600833873100115153191
of325427600833756
the33262760083216094
HELP343627600834477109144
study35962760083264987126158
extension.37692760083346690124162188203241279293
Clin40772760083405570108
Transl42002760083335083121147163
Allergy.43782760083415671106128166198208
2017;7:36.460127600833468100130139172182217252265
17.30472860085366876
Valerieva31402860083366782117138154189221254
A,341028600834155
Senter348128600833368106128161182
R,368028600833549
Wu374528600835894
MA,385628600835496110
et398228600833457
al.40552860083324760
Lanadelumab413128600833265103135175209225263320353392
for45392860083185678
the46332860083226095
prevention47442860083396094127161199220236274312
of507228600833857
attacks51452860083325478111143173202
in536328600831553
hereditary54322860083387330472960083215594109132165186220
angioedema.328229600833270109124162198237272330362376
Expert367329600833365105140161186
Rev387429600833671103
Clin39922960083405570108
Immunol.411629600831472130168206244260273
2019;15(12):1239-1248.440429600833468100130143173203221253282300312342372407440464494524556592606
18.30473060085366985
Buttgereit31493060083357396120158193214248263286
T,345230600833241
Vera35103060083366890123
C,365030600834053
Weller372030600835790106121156177
K,391430600833549
et398030600833457
al.40543060083314760
Lanadelumab413130600833164102135174209224262320352391
Efficacy,4539306008333516886118151183217227
Safety,47833060083326584118141174184
and498430600833270109
Injection51103060083155368103135159175213251
Interval5378306008315537410812930473160083326480
Extension31403160083326589123161187202240278
in343131600831452
HAE:349631600834485118131
A3640316008341
Real-Life369431600833670102118140173188207242
Study.39493160083325391130162172
J4134316008324
Allergy41713160083415671106127165197
Clin43813160083405570108
Immunol450231600831472130167205243259
Pract.47743160083355689121145158
2021;9(10):3744-3751.494531600833468101132141176195227258276288323355386422445478510542573583
19.30473260085366982
Zuraw31463260083387495128179
B,334232600833648
Lumry340832600833168126147181
WR,360632600835894108
Johnston373132600832463101139165189226264
DT,40123260083457786
et411532600833457
al.41893260083324760
Oral426632600834769102117
once-daily440032600833876108142165206238253268300
berotralstat47173260083397495133155176209224250274306328
for50623260083195678
the51573260083226095
prevention52693260083396094127161199220236304733600833776
of314133600833756
hereditary32153360083387394128167183205238259293
angioedema352633600833270109124162197237272330362
attacks:39063360083325478111143173202214
A4138336008341
randomized,41973360083215492131169227242271305345358
double-blind,457333600833876114153169204227267283298336375387
placebo-controlled49783360083395587119153192231254288325363385406444460475509549
phase304734600833977109136171
33233346008335
trial.3283346008321435991106119
J3417346008324
Allergy34573460083415671106127165197
Clin36703460083405570108
Immunol.379334600831573130168206244260273
2020.408234600833468101135147
20.30473560085367287
Longhurst315235600833169107146184222243270293
H,346335600834457
Cicardi35383560083395587120141179194
M,375035600835467
Craig38353560083406194109148
T,400135600833241
et406035600833456
al.41343560083314760
Prevention42113560083355690122157195216232270308
of453735600833756
Hereditary461135600834479100134174189211244265299
Angioedema492835600834179118133171207246281339372
Attacks53173560083416287120152182211
with30473660083516689127
a3189366008332
Subcutaneous323636600833370109142180202235273308347385411
C1366236600834072
Inhibitor.37503660083155291106145160183220241252
N4017366008345
Engl407736600833370109125
J4217366008324
Med.425636600835590129143
2017;376(12):1131-1140.441436600833468100129139174206238257289319337349378406436467486516544575611624
21.30473760085367082
Bernstein31463760083357092130157180214229267
JA,34293760083246478
Li352437600833147
HH,358737600834489102
Craig37053760083406194109148
TJ,38693760083335466
et395237600833456
al.40243760083324760
Indirect41013760083155392107128162195219
comparison433637600833168127166199220236262300338
of469137600833756
intravenous4764376008314527495128160194232270309335
vs.51153760083325973
subcutaneous520437600832663102135173195228266301304738600833775102
C1-inhibitor31623860083407291107145183198237253275312334
placebo-controlled35093860083395587119153192231254288325363385406444460475509549
trials4072386008321435890106132
for42183860083185677
routine43093860083205896118134172207
prevention45293860083396095127161199221236274312
of485538600833757
hereditary49253860083387394128168183205238259293
angioedema523238600833270109124162197237272304739600835790
attacks.31523960083325478111143173202215
Allergy33833960083415671106127165198
Asthma35963960083416992130188220
Clin38313960083405671108
Immunol.395539600831572130168206244260273
2019;15:13.424339600833468100130143173203214244274287
22.30474060085367288
Reshef31514060083357097135170189
A,335640600834155
Hsu342640600834470108
C,354940600834053
Katelaris36184060083346890124139171193208234
CH,38684060083408497
et398040600833457
al.40524060083324760
Long-term412840600833168107146168191224246304
safety44484060083265978112135168
and463240600833270109
efficacy4756406008334537088120153185219
of499040600833857
garadacimab50624060083397192125164196229244301334373
for54504060083195678
preventing30474160083396095127161199221236274314
hereditary33814160083387394128168183206239260294
angioedema369541600833270109125163198238273331364
attacks:40794160083325478111143173202215
Phase431441600833673106132167
34502416008334
open-label455641600833877113151174190222262297313
extension48904160083346590124162188203241280
study.51904160083265088127159169
Allergy.5379416008341577210712830474260083387080
2025;80(2):545-556.314342600833468101135146181217236270288300335371403425459492526539
23.30474360085367287
Fung315043600833269107146
S.331143600833346
Garadacimab:33724360083447698131170202234249307339379391
First3778436008333476996119
Approval.391243600834181120142179211244259272
Drugs.420043600834567105144170184
2025;85(6):827-832.439943600833468101136147182216234267285297332365398417453487519532
24.30474460085367186
Riedl31494460083355186125140
MA,330644600835496110
Tachdjian34324460083336193131170185200232270
R,371944600833549
Lumry378444600833168126147181
WR,398244600835794107
et410644600833456
al.41784460083324760
Efficacy4254446008333516886118151183217
and448744600833270109
Safety46124460083336584119141175
of480344600833757
Donidalorsen487644600834584122137176208224262283311346384
for52764460083185677
Hereditary53704460083447910013430474560083385376108130164
Angioedema.322645600834179118133171207246281339372385
N3626456008345
Engl368645600833371110125
J3826456008324
Med.386645600835489129142
2024;391(1):21-31.402345600833468101133145180213245260292307318354385404436467476
25.30474660085367287
Riedl31474660083355185125140
MA,330046600835496110
Bernstein34234660083357091130156179213228266
JA,37014660083256478
Jacobs37924660083245689125165191
JS,39964660083245669
et407846600833456
al.41474660083314760
Donidalorsen421946600834684122137176208224262283310345383
Treatment46154660083335084115137195230268289
of491746600833757
Hereditary498646600834479100134174189211244265299
Angioedema529846600834179118133171206304747600833872130162
in322247600831452
Patients32874760083356688103137175196224
Previously35234760083355690122137175213239254285
on382147600833775
Long-Term390947600833168106145167197227248306
Prophylaxis.42284760083355592131170200216248279294320334
J4574476008324
Allergy46114760083415671105126164196
Clin48204760083395469107
Immunol493947600831572130167205243259
Pract.52104760083355688120144157
2025.538047600833468100135147
26.30474860085367187
Cicardi31474860083405587120141179194
M,335548600835467
Bergamaschini34364860083357091129162220252278311349364402417
L,386648600833145
Cugno392448600834076115153192
M,412948600835468
et421048600833456
al.42794860083324760
Long-term435248600833269107146169191225246304
treatment46704860083214377109130188224262283
of496648600833757
hereditary50364860083377294128167182205238259293
angioedema534248600833270109124162304749600833473108166199
with32664960083506688126
attenuated34124960083325478112150187220241275315
androgens:374749600833169108130167206241279306318
a4085496008332
survey41374960083266384119153185
of434249600833756
a4418496008332
13-year44704960083346486118152184205
experience.469549600833465105140162177212250282316328
J5043496008324
Allergy50874960083415671106127166198
Clin53054960083395570108
Immunol.543249600831573304750600835795133171187200
1991;87(4):768-773.326250600833565100132140176209225258275287320352388411442476511523
27.30475160085367078
Gelfand31385160083447893112145182220
JA,33715160083246377
Sherins346051600833370104125140177202
RJ,36755160083356273
Alling3760516008341567185122160
DW,3933516008345102111
et405751600833455
al.41255160083324659
Treatment41965160083334983114135192227264285
of449351600833856
hereditary45625160083377292126164179201233253287
angioedema486151600833269108122159194233267324356
with52305160083506587124
danazol.5367516008338701071383047526008328647991
Reversal314952600833569100133153179211225
of338552600833756
clinical3452526008331455995109140172186
and364952600833269106
biochemical37675260083385289121157191248262292324338
abnormalities.411752600833169106143164221252266280302316349375388
N4516526008344
Engl457152600833269107121
J4703526008324
Med.473852600835488126138
1976;295(26):1444-1448.48875260083346395126137171204237253286318335346375405440476498528558593628640
28.30475360085367288
Bork31495360083357495126
K,328953600833550
Wulff335353600835794109129148
K,351553600833550
Steinmüller-Magin35795360083335487102140198236251266301322342398431470485523
L,411653600833145
et417553600833456
al.42465360083314760
Hereditary432053600834479100134174189211244265299
angioedema463453600833169108124162197237272329362
with50105360083516689127
a5151536008332
mutation519753600835795117150172187225264
in547553600831552
the30475460083226095
plasminogen31575460083395587113171186224262302337375
gene.354754600833873111146158
Allergy.37215460083415671106127166198208
2018;73(2):442-450.394454600833468100131143176210228262280292326363396416453486520532
29.30475560085357082
Bork31405560083357292121
K,327255600833448
Wulff333055600835792106125143
K,348455600833548
Witzke35435560083567192122151183
G,373755600834355
et380355600833455
al.38685560083324658
Treatment39365560083324881111132188222258278
of422555600833755
patients42915560083386990104137173194220
with45225560083496485121
hereditary46545560083377191123161175196227247280
angioedema494555600833167105119155189227260317347
with53035560083506485122
the54365560083215891
c.98830475660083314376110144
A>G320256600834082125
(p.Lys330Glu)33385660083195769101128154188220253297312349365
variant3715566008331638398129166187
in391356600831451
the39765660083215892
plasminogen40805660083385384110166180217255293327364
gene.445556600833872109143154
Orphanet462156600834667106143175212246267
J4899566008324
Rare49355660083356787120
Dis.5066566008345608598
2020;15(1):52.51755660083346799132144173202219249263274308340352
30.30475760085357185
Longhurst314457600833167104142179216236262285
HJ,34415760083436779
Lindsay35325760083314582120145178207
K,375157600833549
Petersen38125760083346788121141168202239
RS,40635760083346779
et415457600833355
al.42215760083314658
CRISPR-Cas942915760083397489120154188209251283308342
In464557600831451
Vivo47085760083355182119
Gene483957600834377114148
Editing49995760083326984105120157195
of520657600833655
KLKB1527357600833466101136167
for54525760083185576
Hereditary304758600834479100134174189212244266300
Angioedema.336258600834179118133171207246281339371385
N3762586008345
Engl382258600833370109125
J3962586008324
Med.400258600835489129142
2024;390(5):432-41.415958600833468101133145180213249269302320332367399432452489519529
31.30475960085366981
Cohn314359600834077115153
DM,3310596008346101114
Gurugama343859600834482103141181213271303
P,375559600833540
Magerl380959600835487126161182198
M,402159600835468
et410359600833456
al.41735960083324760
CRISPR-Based42475960083407591123158193215252285312347386
Therapy464759600833372107128161201232
for48935960083185677
Hereditary498459600834480101135174190212245266300
Angioedema.529859600834179118133171207304760600833873131163177
N3239606008345
Engl329960600833370109125
J3439606008324
Med.347860600835590129143
2025;392(5):458-467.363660600833468101136147182215248265299317329364396431453490526559565
32.30476160085367186
Buttgereit31516160083357396120158193214248263286
T,345461600833241
Aulenbacher35126160083417893128166206239271309344365
F,389461600833238
Adatia394961600834180112134149181
A,414761600834155
et421961600833456
al.42926160083324760
Unmet436961600834482140175197
needs458361600833772108147174
in477461600831452
hereditary48436160083387394128168183205238259293
angioedema:515361600833270109124162198237272330362375
an304762600833270
international31326260083155374108129168200222237275314346361
survey35096260083266384119153185
of370962600833756
physicians.378162600833877108135149181197229267293306
Orphanet410362600834769108147179217252274
J4393626008324
Rare44326260083366890124
Dis.45716260083456187100
2025;20(1):383.468762600833468101136147182216235267281293328363397409