951
HLAVNÍ506722001005185134178232252
TÉMA533422001003981147194
Dyslipidemie394533001004582112127142180196234269329345380
u4341330010037
kardio-reno-metabolického43943300100336993131146185211235270308347373433468495531569608624639670704738776815
syndromu522533001002865104142166205265302
|5584220010018
387564222001003476108
/35898040010732
Vnitř3666804001074592111139166
Lék.3851804001074184122140
2026;72(6):382-3874011804001074487128170185227270291333356370415458500526567610651
/47078040010732
VNITŘNÍ48058040010746106127172220280301
LÉKAŘSTVÍ5127804001074184130188235280325377399
www.casopisvnitrnilekarstvi.cz42580400107651332012142542953293774274464795215705896176436927117307748128548809159449871007102310631101
22.425550085367288
Sattar525550083326587111143164
N,7025500834457
Lee7725500833165100
MMY,88555008354109144152
Kristensen105055008334567298121154192218253291
SL,1353550083336477
et14435500833456
al.1511550083324760
Cardiovascular,1584550083407293131146184215248274306344359391412422
mortality,20185500835795117141174189204226259269
and23005500833169108
kidney2421550083294584122156188
outcomes2621550083377598128165223257284
with425650083506587125
GLP-15626500834375110130161
receptor735650083205486119158179216237
agonists9846500833170107145160185208235
in12316500831552
patients1295650083397192107141179200227
with1534650083506587125
type1671650083225594129
2181265008334
diabetes:1858650083385384123158179213239251
a212165008332
systematic2165650083265884107140197229250265296
review2474650083205485101135185
and26716500833269108
meta-analysis27916500835791425750083225477109147179195227254268295
of7357500833756
randomised807750083205391131169227242268303343
trials.116575008322435991106132146
Lancet13267500833165103135169191
Diabetes1532750083466193132168190224251
Endocrinol17987500833371110148180202217255294309
2021;21237500833468101132141
9:653-662.2279750083344783116149171208244277290
23.425850085367287
Nicholls525850083446091129167183198224
SJ,761850083335769
Pavo843850083356798135
I,9918500831527
Bhatt10318500833573106127151
DL,1195850083457791
et12998500833356
al.;136785008332476073
SURPASS-CVOT14528500833376111147185218250273315353400432
Investigators.1897850083155284118144167182221253275311333360373
Cardiovascular2283850083407293131146184216249275307344360392413
Outcomes270885008347851081381754259500835792119
with557950083506688126
Tirzepatide696950083334970101135174207229244283317
versus1026950083326687114151178
Dulaglutide1217950083458398130169185222244260298333
in15639500831552
Type16289500833360100136
2177795008334
Diabetes.1824950083456092131167189223249263
N210095008344
Engl21579500833371109125
J229595008324
Med23329500835489128
2025;24739500833468101136147
393:24092420.263295008335681001121471792142494251050083346699133145
24.4251150085367186
Nahra52411500834577115136169
R,70611500833650
Wang76911500835789127166
T,94811500833341
Gadde100311500834376115154189
KM,120511500833592105
et132411500833456
al.13931150083324760
Effects14661150083335271105138162190
of166911500833757
Cotadutide17391150083407799131170208231246285320
on207211500833776
Metabolic216111500835489112144184222238253285
and245911500833270109
Hepatic258211500834479118151173188220
Parameters28151150083356742512500832154111147169203224251
in69212500831452
Adults76012500834179117132155182
With9581250083587496134
Overweight110812500834781115136190224239278316338
or146112500833859
Obesity153612500834787122149164186220
and177212500833270109
Type189712500833260100135
22048125008334
Diabetes:20981250083456193132168190224251263
A2377125008341
54-Week24341250083346992150183218249
Randomized26991250083356810614518342513500835772102136175
Phase61513500833673105132167
2797135008334
b844135008338
Study.8971350083335492131163173
Diabetes10851350083466193132168190224251
Care13511350083407394128
2021;149413500833569102133141
44:1433-1442.16511350083347183113144176209231262293330363375
25.4251450085367287
Ji52514500832439
L,57714500833145
Jiang6351450083243971109148
H,79614500834457
Cheng86614500834078112151189
Z,106814500833851
et113214500833456
al.12011450083324760
A1274145008341
phase132814500833977109136171
21512145008334
randomised15591450083215491130169227242268303342
controlled191414500833168107128149187203218252292
trial2219145008321435890106
of233814500833756
mazdutide240714500835790119157195217232271306
in272614500831553
Chinese279214500833977924251550083387399134
overweight57515500833769103124178212227266304326
adults91615500833271108124146174
or110515500833759
adults117915500833271109124146174
with13691550083506688126
obesity.151115500833776112139154176210220
Nat17461550083457799
Commun186015500834077135193231269
2023;214415500833468101136148
14:8289.23071550083346577112146179214225
26.4251650085367186
Briand5241650083355672103141179
F,71616500833238
Augustin76716500834077116153179202217254
R,103416500833549
Wesche109516500835790117148186221
F,132816500833238
et137916500833456
al.14471650083324760
Survodutide15191650083336990125162201238260275314348
Weight188016500835790105143181202
Loss20951650083316894120
Is222816500831541
Associated22811650083416895133165180211233266305
with25991650083506588125
Changes27371650083407710914742517500833873100
in54017500831553
Food60817500833269108148
Preference7711750083355690109143165199237269303
and108917500833270109
Improvement121317500831573112133171202237295330368389
of161817500833756
Dyslipidemia168917500834678105121136175190229264322337369
in207317500831553
the21411750083226095
Free22511750083325286122
Choice238817500834078116131163197
Diet–Induced2600175008345619611815216820624528342518500833165104
Obese54518500834787122149184
Hamster74418500834477135161184218239
Model.99818500835593133168183196
Diabetes12101850083456092132167189223250
2024;147518500833569101133145
73163618500833468
(Supplement_1):17191850083195188127167182217275310348370407439453465
1635–P.22001850083346599132168205210
27.4251950085357078
Rosenstock5151950083357298132170195218254286315
J,84219500832436
Frias890195008332516697123
J,102519500832435
Jastreboff10731950083235581103124157195233253271
AM,135719500834094107
et147619500833456
al.15441950083314658
Retatrutide,16141950083356991123144165202224239277311323
a1949195008331
GIP,1992195008343589397
GLP-1210119500834375110130160
and227319500833269107
glucagon23921950083385289120153191228266
receptor26701950083205385118156178214235
agonist,42520500833270108146160186209222
for6592050083195677
people74920500833873111150166200
with9622050083506587125
type10992050083225595130
21241205008334
diabetes:12882050083375284122158179213239251
a1552205008331
randomised,15962050083205390129167224239265299338351
double-blind,195920500833876113152168202225264280295332370383
placebo23542050083395486118151190228
and259520500833169107
active-27152050083316387102134168190
-controlled,4252150083215491129151172209225240275314327
parallel-group,7652150083387192125141156190206228268289327365404415
phase119321500833977109136171
21376215008335
trial1423215008322435991106
conducted154221500833168106145183215239272312
in186721500831452
the19322150083215994
USA.203921500834476116131
Lancet218321500833165102134168190
2023;238621500833468101136147
402:529-544.254621500833470102115150183217241274310346359
28.4252250085367288
Jastreboff5322250083245683106127161201240259278
AM,82922500834196110
Kaplan95822500833468107123155193
LM,117022500833187100
Frías12892250083325268100126
JP,14342250083246064
et151722500833456
al.;1592225008332476073
Retatrutide16832250083367193126147169207230245284319
Phase202022500833573105132167
22205225008334
Obesity225822500834787122149164187220
Trial2497225008332506597113
Investigators.262822500831553841191451691842232554252350083225980107121
Triple-Hormone-Receptor5622350083325065104120155178224262284342381419454477514549582616655677714736
Agonist131323500834180118156171198221
Retatrutide15492350083367193126148169207230245284319
for18842350083185677
Obesity197723500834787123149164187220
-2213235008321
A2250235008341
Phase230723500833572104131166
22489235008334
Trial.2539235008332506597113125
N2680235008345
Engl274123500833270109124
J2881235008324
Med42524500835490129
2023;56924500833569102136148
389:514-526.73224500833469103116151182213236270303337350
29.4252550085367184
Mach52225500835486118155
F,68925500833338
Koskinas7402550083347197127143180212238
KC,9902550083357386
Roeters108825500833573108130163184211
van131125500833264101
Lennep142525500833165102140174213
JE,16502550083245770
et173225500833456
al.;1800255008331465971
ESC/EAS188425500833265105132165207241
Scientific21372550083326479113151172187204221252
Document240225500834583115152209244281302
Group.271725500834364101138177189
202542526500833468101136
Focused57626500833269102140166201241
Update83126500834483122155176210
of105626500833756
the11272650083226095
2019123626500833569100131
ESC/EAS138126500833367107134168211245
Guidelines16402650083448297136171187202240275301
for19562650083185678
the20482650083226095
management215826500835789127160199234292327365386
of255926500833756
dyslipidaemias.2630265008338709711212716618222125342527500833492107139166179
Eur6192750083337091
Heart72527500834479111132157
J897275008324
2025;93727500833468101136146
46:4359-4378.10992750083347082117149182215238275307340373386
30.4252850085367186
Cholesterol52428500834077115130164191214247268304320
Treatment8562850083335083114136193228265286
Trialists’1155285008332496496111125151174201214
(CTT)13812850083185792129150
Collaboration;15442850083397691106138177215236268290305342380392
Fulcher19482850083326883115152186207
J,216828500832435
O’Connell22162850083465999135173210245260275
R,250328500833549
Voysey256528500833570101128162193
M,277128500835467
et285028500833456
al.4252950083324760
Efficacy498295008333506886118151183216
and72729500833270109
safety8492950083265978112135168
of103029500833757
LDL-lowering110029500833177109124140178229264285300338377
therapy14902950083226095116149188219
among172229500833290128166205
men194029500835893131
and208429500833169108
women:220529500835188147182220232
meta-analysis245029500835792114147169201239272287319346360386
of284929500833857
individual4253050083145189103135150187223255269
data7063050083376889121
from8393050083183975131
174,0009823050083346291103137172206
participants12003050083387090114128159173211243280301327
in153930500831451
27160230500833365
randomised16793050083205288126163220234259293331
trials.2022305008321425787102127140
Lancet217330500833164100131164185
2015;23703050083336697126136
385:1397-1405.25183050083336699109138167199231249278308343376387
31.4253150085366981
Cholesterol52031500834078116132167194217251272309325
Treatment8583150083335084116138196231269290
Trialists’1162315008332506597113127154177204217
(CTT)13933150083185793130152
Collaborators;15583150083407793108141180219240273295332353381393
Kearney196431500833569101122161196227
PM,220531500833589102
Blackwell23203150083365184116146199234249264
L,259831500833145
Collins26563150083407793108123161187
R,285631500833650
et42532500833456
al.4993250083324861
Efficacy578325008332506886118151183216
of81332500833756
cholesterol-lowering88732500833270108124159186209242264301317339355394445479500516554593
therapy14983250083226095116149188220
in173632500831452
18,68618073250083346578113149184
people200932500833975113153169204
with22313250083506688127
diabetes23763250083385385124160182216243
in263732500831552
14270832500833465
randomised2791325008321549242533500833876135150176211250
trials691335008321435890106132
of83833500833757
statins:9103350083264982104119157183196
a1121335008332
meta-analysis.116833500835793115148170202240273288320347362388401
Lancet158533500833165103135168191
2008;179133500833468104140152
371:117-125.19583350083356799108137165194213244274309321
32.4253450085367186
Cannon52934500834073111149187225
CP,7713450083407680
Blazing8683450083355183113129166205
MA,109034500835597111
Giugliano12183450083445996136151166198236274
RP,15093450083357276
et160234500833456
al.;1675345008332476073
IMPROVE-IT176534500831570105141188224258280296330
Investigators.21123450083155384119145169184223255277314335362376
Ezetimibe25053450083336397120135193208247282
Added28043450083418042535500833873112
to55035500832158
Statin6213550083325386108123160
Therapy79435500833372107128160199231
after10373550083325176109130
Acute118035500834172110132166
Coronary13593550083397698135173205226260
Syndromes.163235500833262100139160197255290317330
N1975355008345
Engl203335500833270108124
J2169355008325
Med220635500835590129
2015;23483550083346899129140
372:2387-2397.250135500833466100112147182216249267298333366398404
33.4253650085367186
Giugliano5263650083445997136151166198236274
RP,8153650083357176
Cannon90536500834073111149187226
CP,11453650083407680
Blazing12403650083355183113128166205
MA,146036500835496110
et158536500833456
al.;1655365008332486173
IMPROVE-IT174336500831570105140188224258280296330
(Improved20883650083183391130152189221255295
Reduction239736500833671110148180204219257296
of270736500833857
Outcomes:27793650083468510742537500833168126161188201
Vytorin6443750083356893130151167205
Efficacy867375008332506886118151183216
International11013750083155375108130168201222238276314346362
Trial)1481375008332506597113132
Investigators.16313750083155384118145168184222255276313335362376
Benefit202537500833570108143161178200
of224337500833757
Adding231837500834179118133171210
Ezetimibe25463750083336397120135193208247282
to284637500832259
Statin4253850083325486108123161
Therapy60438500833271106128161200231
on85338500833775
Cardiovascular9463850083397293132147185217250276308346362394415
Outcomes137838500834786108139176234269296
and169138500833270109
Safety18183850083326584118141174
in201038500831452
Patients20803850083356788104138176198226
With23233850083577496134
Versus24753850083356889116154180
Without26723850083587496134173211233
Diabetes4253950083456193132168190224250
Mellitus:69339500835490105120135158196222234
Results9453950083357097134150172200
From11623950083325289148
IMPROVE-IT132739500831570106141189224259280297331
(Improved16753950083193491131152189221256295
Reduction198839500833570110147179203219257295
of230139500833756
Outcomes:237539500834785108138175234269295308
Vytorin27003950083366993130152168205
Efficacy425405008333506886118151183217
International6574050083155374108129168200222237275314346361
Trial).1034405008332496597112132143
Circulation11924050083405576107145161193214230268306
2018;151440500833468100131143
137:1571-1582.16724050083346496106136166200232251282312346379392
34.4254150085357185
Baigent5214150083356680117150187207
C,73841500834051
Landray8004150083316399136156187217
MJ,10274150083547889
Reith11264150083356982103140
C,127641500834051
et133841500833354
al.;1403415008331455768
SHARP148241500833274113147182
Investigators.16744150083155181114139161175212242263298318344356
The204141500833269103
effects21544150083345270103134157183
of234841500833654
lowering241341500831451100133153167203240
LDL266441500833175105
cholesterol278041500833167104425425008315487496129149185200
with6364250083506586123
simvastatin7704250083264096126158184206237258272309
plus10904250083385390115
ezetimibe12164250083346295116130187201239273
in150042500831551
patients15624250083397191106139176196223
with17964250083506586123
chronic19304250083316888124161175206
kidney21474250083304583119153184
disease23424250083385277110141167200
(Study25544250083184969105143174
of273942500833755
Heart2805425008344784254350083325276
and51243500833269107
Renal63043500833569106138152
Protection):7944350083355491112144176199214251288305316
a1121435008332
randomised11644350083215390128165222237262296334
placebo-controlled15104350083385384116148187225247280316353374394431446460494532
trial.2054435008321425687102114
Lancet217943500833264101132165186
2011;23774350083346798125132
377:2181-2192.25204350083346599108142173203234252282312342374385
35.4254450085367186
Singh5314450083324785124162
A,71344500834155
Kesani7894450083356996129167182
H,99144500834457
Verma10694450083356889148180
S,126944500833346
et133544500833456
al.14124450083314760
Cardio-Renal14924450083407394132147185208246281319351366
Metabolic187944500835489112144184222238253285
Syndrome:218544500833262101140161198256291304
An250944500834179
Integrated26094450083145274108147168201223257296
Approach42545500834180120141179212244282
to72245500832259
Prevention7964550083355690122156195216231269308
and111945500833270109
Management.124345500835587125158197232289325363384397
Cureus16564550083407697131169195
2025;186745500833468101136147
17:e94134.20294550083346374108143178209239274287
36.3047550085367287
Monami31475500835492131163220235
M,33955500835467
Sesti3475550083336794117132
G,36205500834457
Mannucci36905500835486124162199231262277
E.39795500833346
PCSK940385500833575109143178
inhibitor4229550083145290105144159181218239
therapy:4481550083226094116148187218232
A472555008341
systematic4779550083265885108142199231253268300
review5092550083205486102136187
and52925500833269108
meta-analysis541355008357923047650083225477109147179194226253268294
of33546500833756
metabolic34236500835792114147186225241256287
and37236500833270109
cardiovascular3845650083316485123138176208241267299337352384405
outcomes4263650083377598129165224258285
in45616500831553
patients4626650083397294109143181203231
with4869650083516689127
diabetes.5009650083385385124159182215242255
Diabetes5277650083466193132168190223250
Obes30477500834787122149
Metab32117500835590112145184
2019;34117500833468100130143
21:903-908.3569750083346674109145178200235271306320
37.3047850085367181
Imbalzano31458500831573113147163193227266305
E,34678500833246
Ilardi353085008315316486124140
F,36878500833339
Orlando3743850083477086119158198237
L,39978500833145
et40598500833457
al.4134850083314761
The42128500833373108
efficacy433785008334537189122155188223
of45778500833757
PCSK946518500833576111146182
inhibitors4850850083155392108148164187225247275
on51428500833776
major52368500835790106145167
cardiovascular54208500833165873047950083385493125159186219258274307328
events33939500833467102141163192
and36039500833270110
lipid373195008315317187126
profile3876950083386098117134150185
in40799500831554
patients4151950083387294110146185207235
with4404950083516790129
diabetes:4551950083385487127163186221248261
a483095008332
systematic4880950083276087111146204237260276309
review5207950083205588105140192
and54179500833270110
meta-analysis304710500835894117151175208247281297330358374401
of347010500833858
randomized35501050083215594135174233250280315356
controlled392810500833169109132154192209225261302
trials.4252105008322456194111138152
Eur44261050083337193
Heart454110500834581114136162
J4725105008324
Cardiovasc47711050083417597136152191225259286320
Pharmacother511310500833574107129189223256294317356392414
2023;304711500833469103138150
9:318-327.32141150083344884115147170204237270277
38.30471250085367288
Igweonu-Nwakile314912500831554105140178217254277323374407437454469504
EO,36671250083328091
Ali37721250083405671
S,385712500833245
Paul391612500833567104120
S,404912500833346
et410912500833356
al.41791250083314760
A4252125008341
Systematic43071250083336289113146204237258274306
Review462612500833671103119153205
on484412500833876
the49341250083226095
Safety50431250083326584118141174
and523112500833270109
Efficacy5354125008332506886118151304713500833165
of312913500833757
PCSK9320313500833576110144180
Inhibitors34001350083155391106145161183220242269
in368613500831553
Lowering375613500833269120155176191229268
Cardiovascular40421350083407394132147185217250276309347362394415
Risks44751350083355177107135
in462813500831552
Patients46981350083356789104139177198226
With49421350083577396134
Chronic50931350083407899136175190222
Kidney53321350083355290128163195
Disease.30471450083456187122154180215228
Cureus32901450083407697132169196
2022;14:e29140.350114500833468101136148178209221256290324356387423436
39.30471550085367185
Leiter31471550083316681103137158
LA,33211550083317488
Raal342515500833568100115
FJ,35561550083325163
Schwartz363515500833265103153186207232262
GG,391315500834388101
et403015500833456
al.41011550083324861
Inclisiran41771550083155385100115141156177210248
in444115500831452
individuals45081550083155392107140155194232264280306
with48291550083516689127
diabetes49711550083385385125160182216243
or522915500833859
obesity:530415500833776112139154176210223
Post30471650083357299122
hoc318416500833876109
pooled330916500833877116132166206
analyses353116500833169102117149176211238
of378416500833857
the38571650083215994
ORION-9,39671650083478399147193215250261
ORION-1042431650083478499147193216246278
and453716500833169108
ORION-1146611650083478399147193215246274
Phase495016500833673105132167
35133165008334
randomized51821650083215492131169227243272306345
trials.3047175008322435991106132146
Diabetes32081750083456193132168190224250
Obes347417500834787122149
Metab363817500835590112145184
2024;383717500833569102133145
26:3223-3237.39981750083346780115148182217239271304339371377
40.30471850085367489
Landmesser315618500833165103142200235262288323344
U,352018500834455
Ray35951850083356899
KK,37131850083357287
Raal381918500833668101116
FJ,39551850083325164
et403818500833457
al.;4114185008332486073
ORION42071850083478399147193
Investigators.44191850083155384119146169184223255277314335363376
Inclisiran48151850083155385100115141156177210248
in508318500831553
Patients51551850083366789105139177199227
with54011850083516689127
CKD:304719500834074121133
Post31931950083357197120
Hoc332519500834482114
Pooled345219500833571109125159198
Analysis366319500834078110125156183197223
of389819500833756
Three39671950083327192125160
Phase414019500833571103129164
34316195008334
Trials.4363195008332496496111137150
J4525195008324
Am456219500834098
Soc467219500833270103
Nephrol478719500834479118156176213229
2026;502819500833468100133145
doi:51861950083387590102
10.1681/53011950083346577107138173204226
ASN.0000001006.304720500834175119133168204240276312348380412448484497
41.30472150085366981
Cao314621500834073111
YX,32752150083357690
Liu33832150083314784
HH,348621500834488101
Dong360521500834684123162
QT,37852150083477988
et389221500833456
al.39662150083324760
Effect40452150083325170104137161
of422521500833756
proprotein42992150083396198137159196218252267305
convertase462221500833268107138172194218251278313
subtilisin/kexin495321500832663103125140155170196211249275306340372387425
type53962150083225696131
93047225008334
(PCSK9)30972250083185494128163198216
monoclonal332822500835896134173205221259297330345
antibodies36882250083327092107146185225240274301
on400522500833775
new-onset409622500833772123146185224250285308
diabetes44192250083385385124160182216243
mellitus467722500835793108123138161199225
and491722500833270109
glucose50422250083385390123160186221
metabolism:52792250083579211414718622530472350083153056114126
A3188235008341
systematic32442350083265986109143201233255270302
review35612350083215587103138189
and376523500833270109
meta-analysis.389023500835792114147170202240272288319346361387401
Diabetes43062350083456193132168190224251
Obes457223500834787122149
Metab473623500835590112145184
2018;493623500833468100131143
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42.30472450085367086
Li314924500833147
F,321224500833238
Ye326624500833566
H,334824500834457
Chen342124500834078113151
L,358824500833145
et364824500833457
al.37212450083314760
Systemic37962450083336390113147205220252
evaluation40642450083336699114152184206221259297
of437724500833757
inclisiran44502450083145284100115141156177210248
on471424500833775
the48052450083226095
risk4916245008320366292
of502424500833757
new-onset509624500833873124146186225251286308
diabetes5420245008338538530472550083397496130157
and322325500833270109
hyperglycemia335225500833768108143165203218250281315373388420
compared379125500833268127166199220254294
to410425500832259
evolocumab418225500833466104120158190228286318358
and455925500833270109
atorvastatin.46872550083325491112147180207230262284300337351
Front50572550083325289128149
Pharmacol522625500833572104126184216249285301
2025;304726500833468101136147
16:1554631.32092650083346578108138170205241275306316
43.30472750085377389
Nissen31572750083466289116152192
SE,33702750083336780
Lincoff34722750083324887120158179198
AM,369227500834299113
Brennan38262750083365994133172206245
D,409227500834758
et417127500833558
al.;4251275008332486275
CLEAR434827500834073107151188
Outcomes455827500834887111143181241277305
Investigators.48842750083155487122150174190230263286324346375389
Bempedoic52942750083367313217320930472850083387692124
Acid31862850083417388127
and332828500833270109
Cardiovascular34532850083407294132147185217250276309346362394415
Outcomes388428500834785108138175233269295
in419528500831553
Statin-Intolerant42632850083335486108124161184200238260297313348369402440461
Patients.47402850083356789104139177198226240
N4995285008345
Engl505628500833270109124
J5196285008324
Med523628500835489129
2023;538028500833469101136148
388:1353-1364.304729500833469104116146176209242264295325359396408
44.30473050085367490
Leiter31533050083316681103137158
LA,33273050083327589
Banach343230500833669107139171209
M,365730500835568
Catapano37423050083397294127166199237275
AL,40333050083417387
et413630500833456
al.42093050083314760
Bempedoic428530500833570128168203243281296328
acid46293050083326480118
in476430500831452
patients48323050083397294109144182203231
with50793050083516689127
type52223050083225696131
25369305008335
diabetes5420305008338538530473150083397597131159
mellitus,322631500835893109125140162201227241
prediabetes,34873150083396195135151183223259281315342356
and386331500833271110
normoglycaemia:39943150083387698157196236251283315348384442457490502
A4517315008341
post457931500833978105128
hoc472831500833876109
analysis485831500833270103119151178193219
of509831500833857
efficacy5176315008334537189121154187221
and541731500833271110
glycaemic30473250083385385117150184242257289
control335632500833168107128150187203
using35793250083376378116155
pooled375432500833877116132167206
data39803250083387092125
from41243250083194178136
phase428032500833977110136171
34471325008334
clinical4525325008331466199114146179194
trials.4739325008322435991106132146
Diabetes49053250083456092132167190223250
Obes517532500834787122149
Metab534432500835489112144184
2022;304733500833468101136148
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45.30473450085367286
Ray31543450083356899
KK,32733450083357287
Bloedon33803450083355189125165203241
L,364234500833145
Li370734500833247
N,377434500834558
Nissen38523450083456086113148186
SE;40593450083326578
co-authors.41573450083316892124162184222261282310323
Evaluating45013450083326497113150182204220258297
the48183450083226095
effect49333450083345473107140164
of511834500833756
bempedoic519534500833874132171207246285300332
acid30473550083326479118
on317935500833876
kidney32703550083294684122157189
function:34733550083195795128152167205244256
call3743355008331648095
for38523550083185678
cautious394435500833164102124140178216242
implementation420135500831472111127162220255293314347369384422461
-4676355008321
Authors’471235500834178100138177198225238
reply.49653550083205494110141151
Lancet513135500833165103135169191
Diabetes5336355008346619313216830473650083225582
Endocrinol.314536500833270109147180201217255293309322
2024;348236500833468101133145
12:228-229.36423650083346477112147180203234269303314
46.30473750085367489
Stemmer31533750083325487145203238259
K,342937500833549
Finan34953750083324785117155
B,366737500833548
DiMarchi373137500834561116149170201239254
RD,40013750083368293
et411037500833457
al.41833750083324760
Insights4259375008315538094133171193220
into44963750083145274111
incretin-based46233750083155385106140163178216238278311338373412
therapies50523750083216095116149188203238265
for53333750083195678
treatment54273750083224378304738500833254112147185206
of326938500833756
diabetic33413850083385385124160182197229
dyslipidemia.35853850083387097113128167182221256314329361374
Adv397538500834179112
Drug410238500834567105144
Deliv42623850083458096111143
Rev442138500833570102
2020;453938500833468101135148
159:34-53.47023850083346497110145180203237270283
47.30473950085367079
O’Brien31473950083476097119135169208
RC,33753950083367790
Abdallah348639500834180120153168184216254
K,376139500833550
Dong383139500834685123163
X,401439500833952
et408739500833456
al.41643950083324760
Delphi42453950083468197136175190
Consensus445639500834077116142177216242280306
on478339500833776
the48803950083216095
Use499639500834469105
of512139500833857
Fenofibrate519939500833266105143161178217239272294328
as304740500833259
Systemic31274050083336390114148206222254
Therapy340240500833373108130163203235
for36574050083195779
the37574050083226096
Prevention38744050083355691123158197218234272311
of420640500833857
Diabetic42844050083466294134170193208241
Retinopathy45454050083367194110148187227260282321352
Progression.49184050083355694134156190217244259298337350
J5289405008325
Diabetes5334405008346629413417030474150083225582
2026;314541500833468101134147
18:e70193.33074150083346577112144178209240272285
48.30474250085367490
Bhatt315142500833574106128152
DL,33174250083467891
Steg34234250083325387127
PG,35644250083357993
Miller36714250083557085100135156
M,384242500835467
Brinton39244250083355672110131168207
EA,41454250083337590
Jacobson42494250083245688125165191230268
TA,45314250083337084
Ketchum46294250083357092123161198256
SB,48994250083336880
Doyle499442500834584115131166
RT517442500833569
Jr,52574250083254656
Juliano5327425008324627792124162201
RA,30474350083357892
Jiao31574350083254072110
L,328543500833145
Granowitz33484350083446598136175226241264294
C,366143500833952
Tardif37314350083336182120135155
JC,39044350083246578
Ballantyne4000435008335688499131169190224263298
CM;431643500834095108
REDUCE-IT444243500833569114159199232253270304
Investigators.47644350083155384119145169184223255277314335362376
Cardiovascular5158435008340739413214718521725027730934730474450083154768
Risk31324450083355177107
Reduction325544500833570110147180204219257296
with35674450083516689127
Icosapent37104450083154784111144183219257278
Ethyl40054450083325392122138
for41604450083185677
Hypertriglyceridemia.425444500834476116151172197219234273288320352385406422461496554569601614
N4885445008344
Engl494644500833270109125
J5087445008324
Med.512844500835489129142
2019528644500833469100131
Jan54334450083245694
3;380(1):11-22.30474550083344681115150170202216228258285304335370382
doi:34454550083387691103
10.1056/NEJMoa1812792.35644550083346578109140174208234279313339394432465495526558588621654688700
Epub427945500833372110149
2018444445500833468100131
Nov459045500834583115
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PMID:481445500833589104150163
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Praha75971700367175286438609764
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května117174700357149299439536695836
2027206774700357156304447589
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kongres10625660046116435655475585710301163
diabetologie7336010061129643269298012351416169418292109239225282782
pro73364000611296486765
praxi15946400061129648673910001135
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