HLAVNÍ TÉMA Nespavost u pacientů s chronickou obstrukční plicní nemocí: patofyziologie, diagnostika a léčba | 305 / Vnitř Lék. 2026;72(5):300-305 / VNITŘNÍ LÉKAŘSTVÍ www.casopisvnitrnilekarstvi.cz Farmakologická léčba má být rezervována pro vybrané situace, individualizována a pravidelně přehodnocována. Benzodiazepiny a Z-hypnotika vyžadují zvýšenou opatrnost a zolpidem nelze obecně označit za respiračně neutrální. Antagonisté orexinových receptorů mají příznivá krátkodobá data u selektovaných pacientů, avšak jejich bezpečnost u těžké CHOPN a overlap syndromu musí být dále ověřena. PROHLÁŠENÍ AUTORŮ: Prohlášení o původnosti: Publikace byla zpracována s využitím uvedené literatury a nebyla publikována ani zaslána k recenznímu řízení do jiného média. Střet zájmů: Žádný. Financování: Ne. Registrace v databázích: N/A. Projednání etickou komisí: N/A. LITERATURA 1. Agustí A, Celli BR, Criner GJ, et al. 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