584
HLAVNÍ506722701005185134178232252
TÉMA533422701003981147194
Orální260533701004772107123160176
semaglutid279733701002864124159197212250277293331
–3144337010038
Rybelsus®,319833701004279118154169198236264322334
první354833701003762100139154
agonista371833701003472111149164193220257
GLP-1399133701004375117142164
receptoru41713370100235889123161187226251289
pro447633701003762100
perorální45923370100387398136161196212249264
použití487333701003776114146161188204
v5094337010035
klinické51453370100335065102118148182217
praxi53783370100376197134150
|5584227010018
955617227010067101
/36318043010757
Vnitř37078043010771118137165192
Lék.3918804301074184122140
2022;68(2):89-954078804301074487128172187232277301343366380424467497541584
/46828043010757
VNITŘNÍ47598043010791152172217266326346
LÉKAŘSTVÍ5126804301074185131189236280326378400
www.casopisvnitrnilekarstvi.cz42580430107651332012142542953293774274464795215705896176436927117307748128548809159449871007102310631101
11.425553085366678
Zinman518554083395593150183221
B,7545540833750
Aroda8195540834264101140173
VR,1007554083377488
Buse11105540833775101136
JB12615540832662
et13385540833658
al.1411554083344962
PIONEER1488554083375199145178211246
8174955408336
Investigators.1800554083165486120147170185224256278315337364378
Efficacy,219355408334527087119152185218228
Safety,2436554083346786120143176186
and26375540833472111
Tolerability2763554083346884119425654083215493108124139161195
of6356540833756
Oral7076540834668101116
Semaglutide8396540833267125157196211249271287326360
Versus1215654083356889116153180
Placebo1410654083354982114148187226
Added16516540834079118153192
to18596540832158
Insulin1932654083145279116131146184
With2131654083577496134
or22816540833658
Without2354654083577396134172210233
Metformin26026540835489112133170192251266304
in4257540831553
Patients493754083356789104139177198226
With734754083587496134
Type8847540833260100135
2103575408334
Diabetes:1084754083466193132168190224251263
The13637540833271106
PIONEER1485754083354997143176209244
8174575408334
Trial.179475408333506597113126
Diabetes1935754083456193132168190224251
Care2201754083407394128
2019;42:2262-2271.23447540833468100130143178211223258293327360380411446479511521
12.425853085366884
Mosenzon5248540835291117152190220257295
O,8358540834455
Blicher90685408333486395133168189
TM,1111854083308599
Rosenlund1225854083337198133171186224262301
S154185408330
et15868540833254
al.1656854083294457
PIONEER1729854083324795140174206242
5198685408332
Investigators.2033854083135082116143166181220252274311332360373
Efficacy242285408330486583115148180214
and26518540832967106
safety27738540832457761104259540832255
of4969540833958
oral570954083396093109
semaglutide6949540832863121154193208245268283322357
in10669540831755
patients1136954083417496111146184205233
with1384954083536891129
type1528954083245898133
2167795408336
diabetes1728954083405587127162184218245
and19889540833472111
moderate21159540835997137172193226248281
renal2412954083225795127142
impairment25709540831674113146161182241276314335
(PIONEER4251054083195469117162195228264
5):7041054083355466
a785105408333
placebo‑controlled,8331054083405689121154194232256289326365386408445461476511550563
randomised,14111054083225593132171229244270305345357
phase178410540834078110137172
3a197110540833668
trial.2054105408323456092108121
Lancet219010540833366104136170192
Diabetes23981054083466294133169191225251
Endocrinol2665105408334711101491812032184251154083387692
2019;53211540833468100130143
7:515-527.6901154083354580111141163197230263269
Erratum9751154083325375108130168225
in:12161154083145264
Lancet129611540833165103135168191
Diabetes15021154083456193132168190224251
Endocrinol176811540833270109147180201217255293309
2019;7:e21.209211540833569100131143176186221255287296
13.4251253085366883
Rosenstock52312540833674101136174200223260293323
J,86112540832537
Allison913125408341577287113151190
D,111812540834556
Birkenfeld11901254083355071102136174193228243282
AL148712540834273
et157612540833456
al.16471254083324861
Effect17231254083335271105138162
of190012540833857
additional197212540833271110125148163201240272287
oral22751254083375992107
semaglutide239712540832762119152191206244266282320355
vs276812540833158
sitagliptin2842125408326414251354083225493109124163185200238
on67813540833776
glycated7691354083375384116149171204244
hemoglobin102813540833772130168208223261301316354
in139813540831452
adults146513540833170108123145173
with16531354083506688127
type17951354083215595130
21941135408333
diabetes19891354083385385124160182216243
uncontrolled224713540833775107144182204225262278293328368
with26301354083506688126
metformin2772135408356911144251454083185678136151189
alone6291454083375290129164
or80814540834263
with8871454083557093131
sulfonylurea:10331454083316883103140179209225263284318350362
the141014540832765100
PIONEER152514540834054102148181214249
31789145408339
randomized18431454083265997136174232247276310350
clinical22081454083365166104119151184199
trial.2423145408326476395110123
JAMA.256214540832868124166180
2019;275814540833873104135147
321:1466-1480.4251554083346798107136168204239263294325361396408
14.4251653085366984
Buse5241654083337197132
JB,6721654083225870
Bode75816540833371111145
BW,91916540833390100
Mertens103416540835287109133167205231
A,128116540833852
Cho134916540833775113
YM147816540833287
et158116540833153
al.16501654083294557
PIONEER17231654083334795140174206242
71980165408332
investigators.20271654083135082116143166181220252274311332360373
Long‑term241516540832967105144166189222244302
efficacy273216540833250688611815142517540833164
and50417540832967106
safety6251754083235675109131164
of80417540833554
oral8731754083345588103
semaglutide99117540832458116148186201238261276314349
and135517540832966105
the14751754083195791
effect15821754083315069103135159
of175617540833554
switching18251754083237590112142180195232271
from21111754083163874132
sitagliptin2258175408324386093131146161200222237274
to254717540831956
oral26181754083345688103
semaglutide2736175408324591161484251854083385391113129168202
in64318540831250
patients7081854083377091107141179201229
with9521854083486486124
type10921854083195393128
21236185408332
diabetes:12831854083365183122158180214240253
a1551185408330
52-week,15961854083326585137172207237252
randomized,18631854083195290129167225240269303343356
open‑label223418540833574110148171187219258294309
extension25591854083316387121159185200238277
of285118540833554
the4251954083226095
PIONEER5351954083355098143177209245
7795195408334
trial.844195408322445991107119
BMJ97919540833590116
Open111019540834787123161
Diabetes12861954083456193132168190224251
Res15521954083357097
Care16641954083407394128
2020;8:e001649.180819540833468101135148183195230265302333365401434445
15.4252053085366883
Rodbard52320540833674114153186207245
HW,784205408344102112
Rosenstock91120540833674101136174200223260293323
J,124920540832537
Canani130120540834173111144182197
LH151320540833277
et160520540833456
al.16772054083324760
Oral175220540834870103118
semaglutide188520540832762120152191206244266282320355
versus22562054083326687114152178
empagliflozin244920540833492132165204219234252269307335350388
in285320540831552
patients4252154083397293109143181203231
with6712154083536891129
type8152154083245898133
2963215408337
diabetes10152154083405587127162184218245
uncontrolled127521540834078110147185207228265281296331371
on166121540833978
metformin:175421540836095117138176197256271309321
the20902154083246297
PIONEER22032154083375199145178211246
22464215408337
trial.2516215408324456193108121
Diabetes26522154083486395135170192226253
Care4252254083407394128
2019;42:2272-2281.56822540833469100131143178211223258293326360381412446480512521
16.4252353085367085
Pratley5262354083416295117132167199
R,74023540834155
Amod810235408346105143183
A,100823540834761
Hoff108423540835088108127
ST122623540833873
et131423540833962
al.13912354083375265
Oral147223540835274107123
semaglutide161023540833167125157196212249272287326362
versus19872354083377193120157184
subcutaneous218623540833169108141179201234273308347385411
liraglutide2613235408320355689128144181204219258293
and42524540833270109
placebo5492454083415689121155194233
in79724540831654
type8672454083235797132
21014245408336
diabetes10662454083405587126161184217244
(PIONEER13262454083205670118164197230265
4):16062454083365466
a1687245408333
randomised,17362454083225593132170229244270305344357
double-blind,210824540834078117156172206230270285300338377390
phase251324540834179112138173
3a270124540833669
trial.2785245408323456092108121
Lancet42525540833165103135169191
2019;394:39-50.63125540833469100131143178212247260295328352386420432
17.4252653085366978
Husain51926540835088115149165203
M,73826540836175
Birkenfeld8282654083425779110145184204239255295
AL,11382654083478094
Donsmark124826540835190130157215249270302
M1565265408361
et164226540833962
al.17202654083385467
PIONEER180326540834156104151185218255
62073265408340
Investigators.21292654083215991126154178193233266288326348376390
Oral253526540835375109125
Semaglutide267626540833874133166206425275408315547793133169
and61027540833776116
Cardiovascular74227540834680102141157196229263290323362378411433
Outcomes119127540835393116148185245281309
in151627540832059
Patients15912754083417496112148187209238
with18452754083577396135
Type199627540833967108145
22157275408340
Diabetes.221327540835167100141177200235263277
N2506275408350
Engl257227540833978118134
J2722275408330
Med276827540836096137
2019;381:841-851.42528540833468100130143178212244253288324354373409443474483
18.3047553085366985
Marso31485540835689110137176
SP,3339554083346973
Bain3428554083377085123
SC,3566554083347588
Consoli36695540834178117143181197212
A389755408342
et39555540833557
al.4028554083334961
SUSTAIN-641055540833477109143180196241264301
Investigators.4421554083175486120147170185224257278315337364378
Semaglutide48145540833469127159198214251274289328363
and51925540833372111
Cardiovascular53185540834174951341491873047654083326591123161176209230
Outcomes32926540834786108139176234269296
in36036540831553
Patients3671654083356789104139177198226
with3912654083516789127
Type40556540833260100135
2420665408334
Diabetes.4255654083456193132168190224251264
N453565408344
Engl45956540833270109124
J473565408324
Med47746540835490129
2016;375:1834-1844.49186540833569100132144179211244255284315349385408439470506543556
19.3047753085366982
Holst31447540834786102128151
JJ,3310754083275163
Gromada33887540834769106164196235268
J.36717540832740
Role3726754083387692127
of38687540834160
incretin3943754083185688109143165181219
hormones41777540834079100159197235270297
in44907540831755
the4560754083256398
regulation4673754083245897135150183204220258296
of49847540834160
insulin5059754083185682119134149187
secretion5262754083296496118152174189227266
in30478540831553
diabetic3115854083385385124160182197229
and33608540833170109
nondiabetic34848540833776114153168200240275297313345
humans.38448540833875133165203230243
Am41038540834098
J421785408324
Physiol42568540833573103131145183199
Endocrinol44718540833270109147180201217255293309
Metab47958540835590112145184
2004;287:E199-206.49948540833469105141153188221254265298329360395418449483519533
20.3047953085357185
Sharma3147954083306798119176208
A,33709540833852
Verma3436954083336586143175
S.36269540832942
Mechanisms36839540835186118155186224238264320346
by40449540833666
Which41259540835492107138175
Glucagon‑Like‑Peptide-14315954083415693125157195233270292324339369402425461494532554568606641663693
Receptor5023954083336799132170192228249
Agonists52879540833875113151165191213240
and304710540833169107
Sodium‑Glucose316910540833068107122159216238284299336368404431465
Cotransporter-236491054083377495116149186212250289310334367388408438
Inhibitors41021054083125087102140156178214235262
Reduce437910540833367106143175208
Cardiovascular46021054083376990128142180211244270302339354386406
Risk50231054083334874103
in514110540831249
Adults520510540833876113128150178
With53971054083557193130
Type304711540833360100136
23198115408334
Diabetes32481154083456092132167189223250
Mellitus.351311540835590106121136158196222236
Can376411540834073111
J3890115408324
Diabetes.39301154083456193132167190223250264
2020;44:93-102.420911540833468101135148183220232267300322353384417429
21.30471253085367082
Rakipovski31441254083346797113152191223250280296
G,345612540834155
Rolin35261254083347288103141
B,368212540833346
Nøhr374312540834382120141
J3900125408322
et393712540833254
al.40071254083304558
The408012540833170105
GLP-1420012540834274110131162
Analogs437712540833978110125163203229
Liraglutide4621125408330456699138154191214229268303
and493912540833068107
Semaglutide506112540833166124156195211248271286325360
Reduce543612540833368304713540833875106140
Atherosclerosis32021354083385896131151188214246261295316353379394419
in363613540831250
ApoE-/-370113540833876115148169193212
and392813540832966105
LDLr-/-404813540832873105126146170188
Mice42511354083526798132
by439813540833566
a4479135408329
Mechanism452313540835286118156188225240265322
That486013540833069101122
Includes4997135408312498196133172206232
Inflammatory524413540831250678411517223026130471454083225980114
Pathways.31771454083356788126177210241268281
JACC347414540832464103141
Basic36301454083366995110142
Transl37871454083335083121147163
Sci39651454083326580
2018;3:844-857.406014540833468100131143178190225261298321357391424430
22.30471553085367288
Buse315015540833674100135
JB,33011554083246073
Wexler338915540835891123138173194
DJ,35991554083456880
Tsapas36941554083335588127160187
A3896155408341
et395315540833456
al.40251554083324760
2019410015540833569101131
Update424615540834483123155177211
to:44721554083225971
Management455915540835487125157196231289324362384
of495815540833857
Hyperglycemia503015540834576116152173211227258290324382397429
in547415540831553
Type30471654083325997132
23193165408331
Diabetes,32381654083425687125160181214239252
2018.35041654083316494124137
A3656165408337
Consensus370716540833672109135169205231267292
Report401416540833165103141161185
by421316540833566
the42931654083185589
American439716540833793127147162193225262
Diabetes46731654083425687125160181213239
Association49271654083376489126158172203224238275312
(ADA)525416540831555100138156
and542516540832865102
the30471754083215993
European31551754083306586123161196227265
Association34351754083386591128160175206227242280317
for37671754083165374
the38561754083185690
Study39611754083295087126157
of413317540833453
Diabetes42011754083425788127161183216243
(EASD).44581754083164890124168185196
Diabetes46681754083435889127162184217243
Care49261754083376990123
2020;50641754083316597130143
43:487-493.52221754083316374107143175193229261293306
23.30471853085367287
Dahl315018540834881119134
K,329918540833853
Brooks33671854083385996135166195
A,357718540834458
Almazedi365018540834459117149179213252268
F3933185408335
et398318540833759
al.40571854083355063
Oral413518540835072105120
semaglutide427118540832863121154193208245268283322357
improves464318540831875115136173205240266
postprandial492518540834180107130169191224262301316348363
glucose53041854083405693125162189224
and304719540833270109
lipid3171195408313286783121
metabolism,330819540835590112145184223239254280338351
and367419540833068107
delays37961954083367187119150177
gastric39881954083366895118140155187
emptying,419019540833290129152185201239278291
in449619540831351
subjects456219540832461100116151183207235
with48121954083496587125
type49531954083195393128
25097195408332
diabetes.51441954083365183123158180214241255
Diabetes5414195408343599130472054083397496130157
Obes321920540834787123150
Metab338420540835489112144184
2021;23:1594-1603.358320540833468101133141176211222252282314350373404435470503516
24.30472153085367186
Hjerpsted31482154083456095116156182205239279
JB,34422154083246073
Flint35302154083334863100122
A,366721540834156
Brooks37382154083355794133163192
A3945215408342
et400221540833456
al.40742154083324760
Semaglutide414921540833368126158197212250272288327362
improves452621540831572111133170202237263
postprandial480521540833877104127167188221259298313345361
glucose51812154083385491123160187222
and541821540833270109
lipid3047225408315306984123
metabolism,318622540835691113146185224240255281339352
and355322540833169108
delays36762254083387288120151178
first‑hour3869225408316335482105124163202240261
gastric41452254083387096120141157189
emptying434922540833391130152186202240279
in464322540831452
subjects471022540832562102117152184209236
with49622254083496587126
obesity.510322540833676111138153176209219
Diabetes5338225408344609213116630472354083225582
Obes314523540834786122149
Metab330923540835490112145184
2018;20:610-619.350823540833468100131143178212226261291323347384414444455
25.30472453085367387
Vergès31502454083417495134169195
B,336124540834053
Charbonnel342924540834683116137177216254292328343
B.378824540834053
After38572454083466590124145
the401724540832765101
LEADER413324540833670113158192228
trial4376245408327486496111
and450324540833775114
SUSTAIN-6,463224540833882113148185200246268306318
how496624540834381132
do511324540834482
we521024540835691
explain531624540833971110126159174212
the30472554083226095
cardiovascular31572554083366990129144182214247273305343358391412
benefits358425540834479118153170187209237
of383625540834362
some391325540833270128163
GLP-1409125540834981117138169
receptor42752554083266093126166188225246
agonists?453725540833675114152167193216244269
Diabetes48212554083506698137173195229256
Metab509225540835995117150189
2017;529625540833973105135144
43545625540833972
Suppl304726540833270109149164
1:2S3-2S12.32272654083344378111145167197231261291304
Pro1172792401415793149
více1343792401415076122175
informací1539792401412683115171207294348395421
pište1982792401415783130170222
a22267924014154
volejte:23027924014150106134186213251304332
dokoupilova@solen.cz,2655792401415811516722227933636238944649655165169875578383689492296810171044
58537217924014149103153
20938957924014151110164
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