Vnitřní lékařství, 2001 (vol. 47), issue 7
[Percutaneous transluminal septal myocardial ablation in the treatment of hypertrophic obstructive cardiomyopathy: short-term study].
J Veselka, D Tesar, T Urbanová, P Telekes, T Honěk, J Neuwirth
Vnitr Lek 2001, 47(7):437-443
In 18 patients with symptomatic hypertrophic obstructive cardiomyopathy 18 procedures involving percutaneous transluminal myocardial ablation were performed. The patients were followed up for three months after the procedure. The mean intraventricular peak gradient declined during the intervention from 51 +/- 26 mm Hg to 11 +/- 12.2 mm Hg (p < 0.001). On average 2.7 +/- 1.1 ml ethanol were administered, as a rule into the first septal branch. The target artery was detected in 13 instances by means of myocardial contrast echocardiography and in five instances by haemodynamic investigation. In one instance the procedure was combined with subsequent...
[Complications in administration of contrast media in the catheterization laboratory: a 5-year retrospective study].
F Holm, M Aschermann, A Hornig, S Simek, A Linhart, J Humhal
Vnitr Lek 2001, 47(7):444-449
UNLABELLED: Iodine contrast substances (CS) are used since the twenties of the 20th century. From the chemical aspect benzoic acid derivatives are involved which are classified according to their osmolality (high-low- and isoosmolar) tendency of ionization (ionic and non-ionic) and according to the molecular structure monomers and dimers). Side-effects are due to their osmotic, ionic and chemical action on tissues. They include a number of systemic and organ symptoms (cardiovascular, immunological, haemocoagulation, neurological and renal), from the clinical aspect divided into mild, medium severe and severe. The relatively high incidence of undesirable...
[Pathologic gastroesophageal reflux in patients with bronchial asthma].
Z Plottová, J Dolina, B Novotná, A Hep, P Dítě, P Vlcková, R Kroupa, L Husová
Vnitr Lek 2001, 47(7):450-453
Gastrooesophageal reflux (GER) and asthma bronchiale are frequent diseases. Asthma affects some 3-10% of adults. Gastrooesophageal reflux is present in some 45-89% asthmatic patients. Symptoms of GER are not only gastrooesophageal, and recently increased attention is focused on extraoesophageal symptoms where in particular the relationship of GER and asthma or chronic cough is investigated. At our clinic we implemented a pilot study with the objective to monitor the presence of pathological GER in patients with asthma and to assess whether antireflux therapy will influence the respiratory complaints of the patients. The group was formed by 14 patients...
[Changes in the risk profile and the development of hypertension in the population of Plzen 1987-1989 and 1995-1996].
O Mayer, H Rosolová, M Wiendl, J Simon
Vnitr Lek 2001, 47(7):454-459
OBJECTIVE: To evaluate risk factors and the general risk profile in a longitudinally followed-up cohort of the Plzen population.MATERIAL AND METHODS: The investigation was made in a cohort of 332 men and 280 women selected from the epidemiological study PILS II (Plzen longitudinal study) examined in 1987-1989 and 1995-1995. Both investigations adhered to the standard protocol. Anamnestic data were assessed, anthropometric parameters (BMI). Blood pressure (BP) was assessed by means of a mercury sphygmomanometer using the standard procedure, biochemical parameters were examined from a blood sample on fasting in the routine laboratories of the Faculty...
[Thromboembolic complications in the use of oral estrogen-gestagen contraceptives].
S Smírová, M Chochola, P Varejka, M Aschermann
Vnitr Lek 2001, 47(7):460-464
Deep vein thrombosis is a serious complication of oral contraception. The most serious complication, pulmonary embolism, could be lethal. The relative risk of thromboembolic disease is four time higher in women using oral contraception. Both the amount of estrogen and the type of gestagen can increase the relative risk of thromboembolic disease. Oral contraceptives influence procoagulants, fibrinolytic system and inhibitors of coagulation. The choice of oral contraceptive should be very careful. It is advised to use preparations with less then 50 micrograms of ethinyl-estradiol and the type of gestagen that has minimal metabolic side effects, including...
[Diabetes mellitus in the elderly].
P Pi»hová, J Charvát, M Kvapil
Vnitr Lek 2001, 47(7):465-469
Diabetes mellitus is one of the most frequent chronic diseases of the elderly population with a high prevalence after the age of 65 years. In this group it is a serious cause of increased mortality and morbidity. More than 90% of patients suffer from type 2 diabetes mellitus. The disease takes frequently for a long time an asymptomatic course and if it persists for long it may lead to microvascular complications and is an important risk factor of cardiovascular and cerebrovascular diseases. The objective of treatment of diabetes in old age is in particular to restrict symptomatic hyperglycaemia, but at the same time we must not forget prevention of...
[Concomitant radiochemotherapy in solid tumors].
P Slampa, R Soumarová, P Coupek, H Tichá
Vnitr Lek 2001, 47(7):470-477
The need for improved cancer control led to the investigation of combined-modality therapy for many cancers. This review is an attempt of analysis of possibilities to apply simultaneously both treatment modalities in treatment of cancer diseases and shows the possible mechanism of interaction between chemotherapy and radiotherapy. Further in this review is showed benefits of this method combined therapy and strategies of using chemotherapy and radiotherapy to treat different cancers.
[Leptin--a new acute phase reactant].
P Maruna, R Gürlich, R Frasko
Vnitr Lek 2001, 47(7):478-483
Leptin, 16 kDa protein and the product of the Ob gene was discovered six years ago and characterized as a fat cell hormone which maintains via specific receptors in the hypothalamus by a feedback mechanism the energy balance and body weight. Research conducted during the last three years detected further properties of this protein which include it, in addition to its basic role in mammalian metabolism, also among acute phase reactants. Leptin is as to its structure, pattern of the receptor and the postreceptor transduction mechanism close to the group of cytokines of interleukin 6, in particular the granulocytic colony stimulating factor. During infectious...
[Central salt-wasting diuresis syndrome as a cause of hyponatremia in patients at the internal medicine department].
R Safárová, M Horácková, S Vanková, J Forejt, J Hása
Vnitr Lek 2001, 47(7):484-487
Hyponatremia is a common electrolyte disorder related to central nervous system diseases and is often attributed to the syndrome of inappropriate antidiuretic hormone secretion (SIADH) and on the other hand to the cerebral salt wasting syndrome (CSWS). This syndrome is characterized by hyponatremia due to excessive renal sodium excretion resulting from a centrally mediated process. Given the divergent nature of the treatment it is of paramount importance for a clinician to be able to recognize and differentiate between these two entities. Thus the monitoring of renal function tests, which are needed for earlier diagnosis of effective osmolality disorders,...
[Systemic disease caused by the fungus Aspergillus fumigatus in immunocompromised patients].
M Pospísil, P Kessler, M Kheck, F Bárta
Vnitr Lek 2001, 47(7):488-492
The authors describe an invasive pulmonary Aspergillus infection in three immunocompromised patients (1x plasmacytoma, 1x autoimmune thrombocytopenia, 1x asthma bronchiale) and draw attention to the possible occurrence of this disease also in subjects without serious neutropenia. The common risk factor in all three patients was corticoid treatment. In immunocompromised patients only early adequate and sufficiently long antimycotic treatment gives hope that the infection will be controlled.
[Sideropenic anemia as a manifestation of selective iron malabsorption].
J Straub, E Kolesková, J Haber
Vnitr Lek 2001, 47(7):493-495
The objective of the paper is to draw attention to the not very frequent and thus omitted form of sideropenic anaemia in selective iron malabsorption as the only manifestation of malabsorption syndrome in coeliac sprue. This type should be suspected when examination of blood losses is futile and oral iron administration which is usually administered empirically produces no effect. The authors present the example of two patients with severe sideropenic anaemia where the diagnosis of malabsorption was confirmed only several years after the diagnosis of sideropenic anaemia was established. Evidence of a correct conclusion was permanent normalization of...
[Discovery of blood cells in the 17th century].
M Doubek
Vnitr Lek 2001, 47(7):496-499
Landmark works of the 17th century concerning observations of blood cells are quoted in the article. "Simple" and successively "compound" microscopes made their appearance in the late 16th century and early 17th century. In 1656, Frenchman Pierre Borel, physician-in-ordinary to the King Louis XIV, who first applied the microscope to medicine described a type of "worn" found in human blood. In 1657, Athanasius Kircher, a Jesuit priest and scientist from Germany, examined blood from plague victims, and described "worms" of plague. In 1661, 1664 and 1665, the blood cells were discerned by Marcello Malpighi. In 1678, the red blood corpuscles was described...